Seroatlas · Human Serome Atlas

ACTRT2

Actin-related protein T2

Also known as: ACTT2_HUMAN, Arp-T2, ARPM2, FLJ25424

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TDY3
Gene
ACTRT2
Ensembl
ENSG00000169717
Chromosome
1
Canonical length
377 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this intronless gene belongs to the actin family. Studies have shown that this protein may be involved in cytoskeletal organization similar to other cytoplasmic actin-related protein (ARP) subfamily members. Antibody raised against the human protein has been used to detect the protein by immunoblotting and immunofluorescence microscopy, demonstrating its specific synthesis in the testis, late in spermatid differentiation, and its localization in the calyx. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>Q8TDY3|ACTRT2
     1  MFNPHALDSP AVIFDNGSGF CKAGLSGEFG PRHMVSSIVG HLKFQAPSAE ANQKKYFVGE
    61  EALYKQEALQ LHSPFERGLI TGWDDVERLW KHLFEWELGV KPSDQPLLAT EPSLNPRENR
   121  EKMAEVMFEN FGVPAFYLSD QAVLALYASA CVTGLVVDSG DAVTCTVPIF EGYSLPHAVT
   181  KLHVAGRDIT ELLMQLLLAS GHTFPCQLDK GLVDDIKKKL CYVALEPEKE LSRRPEEVLR
   241  EYKLPDGNII SLGDPLHQAP EALFVPQQLG SQSPGLSNMV SSSITKCDTD IQKILFGEIV
   301  LSGGTTLFHG LDDRLLKELE QLASKDTPIK ITAPPDRWFS TWIGASIVTS LSSFKQMWVT
   361  AADFKEFGTS VVQRRCF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTRT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
146 nTPM

Expression across tissuesHPA

Tissue

  • testis: 146 nTPM
  • prostate: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late spermatids: 5,695 nCPM
  • early spermatids: 1,435 nCPM
  • late primary spermatocytes: 423 nCPM
  • sertoli cells: 8.4 nCPM
  • leydig cells: 6 nCPM
  • peritubular myoid cells: 4.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.38
gnomAD pLI
0
gnomAD missense Z
-0.4
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTRT2 as an antibody target. Whether an autoantibody or antibody against ACTRT2 could matter depends on whether native ACTRT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTRT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • Antibody raised against the human protein has been used to detect the protein by immunoblotting and immunofluorescence microscopy, demonstrating its specific synthesis in the testis, late in spermatid differentiation, and its localization in the calyx.

Canonical record: https://seroatlas.com/gene/ACTRT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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