GK2

Protein identityUniProt · HPA

UniProt accession

Q14410

Gene

GK2

Ensembl

ENSG00000196475

Chromosome

4

Canonical length

553 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable glycerol kinase activity. Predicted to be involved in several processes, including glycerol-3-phosphate biosynthetic process; sperm mitochondrial sheath assembly; and triglyceride metabolic process. Located in sperm midpiece. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q14410|GK2
     1  MAAPKTAAVG PLVGAVVQGT NSTRFLVFNS KTAELLSHHK VELTQEFPKE GWVEQDPKEI
    61  LQSVYECIAR TCEKLDELNI DISNIKAVGV SNQRETTVIW DKLTGEPLYN AVVWLDLRTQ
   121  TTVEDLSKKI PGNSNFVKSK TGLPLSTYFS AVKLRWMLDN VRNVQKAVEE GRALFGTIDS
   181  WLIWSLTGGV NGGVHCTDVT NASRTMLFNI HSLEWDKELC DFFEIPMDLL PNVFSSSEIY
   241  GLIKTGALEG VPISGCLGDQ CAALVGQMCF QEGQAKNTYG TGCFLLCNTG RKCVFSEHGL
   301  LTTVAYKLGR EKPAYYALEG SVAIAGAVIR WLRDNLGIIE TSGDIERLAK EVGTSYGCYF
   361  VPAFSGLYAP YWEPSARGIL CGLTQFTNKC HIAFAALEAV CFQTREILEA MNRDCGIPLR
   421  HLQVDGGMTN NKVLMQLQAD ILHIPVIKPF MPETTALGAA MAAGAAEGVS VWSLEPQALS
   481  VLRMERFEPQ IQATESEIRY ATWKKAVMKS MGWVTSQSPE GGDPSIFSSL PLGFFIVSSM
   541  VMLIGARYIS GVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

84 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.43

gnomAD pLI

0

gnomAD missense Z

-0.05

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• flagellated sperm motility
• glycerol catabolic process
• glycerol metabolic process
• glycerol-3-phosphate biosynthetic process
• sperm mitochondrial sheath assembly
• spermatogenesis
• triglyceride metabolic process

Molecular functions

• ATP binding
• glycerol kinase activity

Cellular components

• extracellular exosome
• mitochondrial outer membrane
• mitochondrion
• sperm midpiece
• sperm mitochondrial sheath

Protein domainsUniProt · Pfam · InterPro

• Carbohydrate kinase, FGGY
• Glycerol kinase
• Carbohydrate kinase, FGGY, conserved site
• Carbohydrate kinase FGGY, N-terminal
• Carbohydrate kinase FGGY, C-terminal
• Glycerol kinase, metazoan-type
• ATPase, nucleotide binding domain
• FGGY family of carbohydrate kinases, N-terminal domain
• FGGY family of carbohydrate kinases, C-terminal domain

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Differentiation
• Glycerol metabolism
• Kinase
• Membrane
• Mitochondrion
• Mitochondrion outer membrane
• Nucleotide-binding
• Spermatogenesis
• Transferase
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of GK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ARMC12
• PLD6