Seroatlas · Human Serome Atlas

ACTR10

Actin-related protein 10

Also known as: ACTR11, Arp10, ARP10_HUMAN, Arp11, HARP11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZ32
Gene: ACTR10
Ensembl: ENSG00000131966
Chromosome: 14
Canonical length: 417 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Focal adhesion sites,Perinuclear theca,Connecting piece,Flagellar centriole,Mid piece,Principal piece

OverviewNCBI Gene

Predicted to be involved in retrograde axonal transport of mitochondrion. Predicted to act upstream of or within microtubule-based movement. Predicted to be located in cytosol; extracellular region; and secretory granule. Predicted to be part of dynactin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>Q9NZ32|ACTR10
     1  MPLYEGLGSG GEKTAVVIDL GEAFTKCGFA GETGPRCIIP SVIKRAGMPK PVRVVQYNIN
    61  TEELYSYLKE FIHILYFRHL LVNPRDRRVV IIESVLCPSH FRETLTRVLF KYFEVPSVLL
   121  APSHLMALLT LGINSAMVLD CGYRESLVLP IYEGIPVLNC WGALPLGGKA LHKELETQLL
   181  EQCTVDTSVA KEQSLPSVMG SVPEGVLEDI KARTCFVSDL KRGLKIQAAK FNIDGNNERP
   241  SPPPNVDYPL DGEKILHILG SIRDSVVEIL FEQDNEEQSV ATLILDSLIQ CPIDTRKQLA
   301  ENLVVIGGTS MLPGFLHRLL AEIRYLVEKP KYKKALGTKT FRIHTPPAKA NCVAWLGGAI
   361  FGALQDILGS RSVSKEYYNQ TGRIPDWCSL NNPPLEMMFD VGKTQPPLMK RAFSTEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTR10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

midbrain: 28 nTPM
hypothalamus: 24 nTPM
cerebral cortex: 22 nTPM
amygdala: 21 nTPM
heart muscle: 21 nTPM
basal ganglia: 20 nTPM

Single-cell type

esophageal apical cells: 238 nCPM
syncytiotrophoblasts: 219 nCPM
cytotrophoblasts: 140 nCPM
early primary spermatocytes: 136 nCPM
decidual stromal cells: 136 nCPM
esophageal suprabasal cells: 123 nCPM

Immune cell

basophil: 15 nTPM
MAIT T-cell: 9.1 nTPM
eosinophil: 8.5 nTPM
non-classical monocyte: 8.4 nTPM
neutrophil: 7.7 nTPM
naive CD8 T-cell: 7.4 nTPM

Brain region

choroid plexus: 8.4 nTPM
cerebellum: 6.6 nTPM
hypothalamus: 5.9 nTPM
white matter: 5.9 nTPM
cerebral cortex: 5.1 nTPM
medulla oblongata: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0
gnomAD missense Z: 1.17
DepMap mean gene effect: -1.53
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

retrograde axonal transport of mitochondrion

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACTR10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTR10 as an antibody target. Whether an autoantibody or antibody against ACTR10 could matter depends on whether native ACTR10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTR10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTR10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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