Seroatlas · Human Serome Atlas

HSPA13

Heat shock 70 kDa protein 13

Also known as: HSP13_HUMAN, STCH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P48723
Gene: HSPA13
Ensembl: ENSG00000155304
Chromosome: 21
Canonical length: 471 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

471 residues, UniProt reviewed canonical sequence.

>P48723|HSPA13
     1  MAREMTILGS AVLTLLLAGY LAQQYLPLPT PKVIGIDLGT TYCSVGVFFP GTGKVKVIPD
    61  ENGHISIPSM VSFTDNDVYV GYESVELADS NPQNTIYDAK RFIGKIFTAE ELEAEIGRYP
   121  FKVLNKNGMV EFSVTSNETI TVSPEYVGSR LLLKLKEMAE AYLGMPVANA VISVPAEFDL
   181  KQRNSTIEAA NLAGLKILRV INEPTAAAMA YGLHKADVFH VLVIDLGGGT LDVSLLNKQG
   241  GMFLTRAMSG NNKLGGQDFN QRLLQYLYKQ IYQTYGFVPS RKEEIHRLRQ AVEMVKLNLT
   301  LHQSAQLSVL LTVEEQDRKE PHSSDTELPK DKLSSADDHR VNSGFGRGLS DKKSGESQVL
   361  FETEISRKLF DTLNEDLFQK ILVPIQQVLK EGHLEKTEID EVVLVGGSTR IPRIRQVIQE
   421  FFGKDPNTSV DPDLAVVTGV AIQAGIDGGS WPLQVSALEI PNKHLQKTNF N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPA13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 32 nTPM
thyroid gland: 26 nTPM
epididymis: 25 nTPM
adrenal gland: 23 nTPM
parathyroid gland: 23 nTPM
bone marrow: 22 nTPM

Single-cell type

plasma cells: 126 nCPM
syncytiotrophoblasts: 95 nCPM
corticotrophs: 79 nCPM
other brain neurons: 54 nCPM
epididymal principal cells: 50 nCPM
pancreatic islet cells: 48 nCPM

Immune cell

basophil: 23 nTPM
NK-cell: 12 nTPM
MAIT T-cell: 11 nTPM
plasmacytoid DC: 8.3 nTPM
naive CD4 T-cell: 7.7 nTPM
naive CD8 T-cell: 7.4 nTPM

Brain region

hypothalamus: 46 nTPM
pons: 37 nTPM
midbrain: 31 nTPM
basal ganglia: 31 nTPM
spinal cord: 30 nTPM
cerebral cortex: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.02
gnomAD missense Z: 1.24
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein refolding

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPA13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPA13 as an antibody target. Whether an autoantibody or antibody against HSPA13 could matter depends on whether native HSPA13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPA13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSPA13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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