NAGK

Protein identityUniProt · HPA

UniProt accession

Q9UJ70

Gene

NAGK

Ensembl

ENSG00000124357

Chromosome

2

Canonical length

344 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q9UJ70|NAGK
     1  MAAIYGGVEG GGTRSEVLLV SEDGKILAEA DGLSTNHWLI GTDKCVERIN EMVNRAKRKA
    61  GVDPLVPLRS LGLSLSGGDQ EDAGRILIEE LRDRFPYLSE SYLITTDAAG SIATATPDGG
   121  VVLISGTGSN CRLINPDGSE SGCGGWGHMM GDEGSAYWIA HQAVKIVFDS IDNLEAAPHD
   181  IGYVKQAMFH YFQVPDRLGI LTHLYRDFDK CRFAGFCRKI AEGAQQGDPL SRYIFRKAGE
   241  MLGRHIVAVL PEIDPVLFQG KIGLPILCVG SVWKSWELLK EGFLLALTQG REIQAQNFFS
   301  SFTLMKLRHS SALGGASLGA RHIGHLLPMD YSANAIAFYS YTFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAGK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

148 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

gnomAD missense Z

-0.43

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• defense response to bacterium
• innate immune response
• N-acetylglucosamine catabolic process
• N-acetylglucosamine metabolic process
• N-acetylmannosamine metabolic process
• N-acetylneuraminate catabolic process
• positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
• response to muramyl dipeptide
• UDP-N-acetylglucosamine biosynthetic process

Molecular functions

• ATP binding
• N-acylmannosamine kinase activity
• muramyl dipeptide kinase activity
• N-acetylglucosamine kinase activity

Cellular components

• cytosol
• extracellular exosome

Protein domainsUniProt · Pfam · InterPro

• ATPase, nucleotide binding domain
• ATPase, BadF/BadG/BcrA/BcrD type
• N-acetyl-D-glucosamine kinase NAGK-like
• BadF/BadG/BcrA/BcrD ATPase family

KeywordsUniProt

• Acetylation
• ATP-binding
• Immunity
• Innate immunity
• Kinase
• Nucleotide-binding
• Phosphoprotein
• Transferase

InteractionsUniProt · HPA

Protein binding partners of NAGK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LNX1