Seroatlas · Human Serome Atlas

POTEF

POTE ankyrin domain family member F

Also known as: A26C1B, POTE2alpha, POTEACTIN, POTEF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A5A3E0
Gene
POTEF
Ensembl
ENSG00000196604
Chromosome
2
Canonical length
1075 aa
Protein class
Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in axonogenesis and cell motility. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1075 residues, UniProt reviewed canonical sequence.

>A5A3E0|POTEF
     1  MVVEVDSMPA ASSVKKPFGL RSKMGKWCCR CFPCCRESGK SNVGTSGDHD DSAMKTLRSK
    61  MGKWCRHCFP CCRGSGKSNV GASGDHDDSA MKTLRNKMGK WCCHCFPCCR GSSKSKVGAW
   121  GDYDDSAFME PRYHVRGEDL DKLHRAAWWG KVPRKDLIVM LRDTDVNKQD KQKRTALHLA
   181  SANGNSEVVK LLLDRRCQLN VLDNKKRTAL IKAVQCQEDE CALMLLEHGT DPNIPDEYGN
   241  TTLHYAIYNE DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
   301  LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH HVICQLLSDY
   361  KEKQMLKISS ENSNPEQDLK LTSEEESQRF KGSENSQPEK MSQEPEINKD GDREVEEEMK
   421  KHESNNVGLL ENLTNGVTAG NGDNGLIPQR KSRTPENQQF PDNESEEYHR ICELLSDYKE
   481  KQMPKYSSEN SNPEQDLKLT SEEESQRLKG SENGQPEKRS QEPEINKDGD RELENFMAIE
   541  EMKKHRSTHV GFPENLTNGA TAGNGDDGLI PPRKSRTPES QQFPDTENEE YHSDEQNDTQ
   601  KQFCEEQNTG ILHDEILIHE EKQIEVVEKM NSELSLSCKK EKDILHENST LREEIAMLRL
   661  ELDTMKHQSQ LREKKYLEDI ESVKKRNDNL LKALQLNELT MDDDTAVLVI DNGSGMCKAG
   721  FAGDDAPRAV FPSIVGRPRQ QGMMGGMHQK ESYVGKEAQS KRGILTLKYP MEHGIITNWD
   781  DMEKIWHHTF YNELRVAPEE HPVLLTEATL NPKANREKMT QIMFETFNTP AMYVAIQAVL
   841  SLYTSGRTTG IVMDSGDGVT HTVPIYEGNA LPHATLRLDL AGRELPDYLM KILTEHGYRF
   901  TTMAEREIVR DIKEKLCYVA LDFEQEMATV ASSSSLEKSY ELPDGQVITI GNERFRCPEA
   961  LFQPCFLGME SCGIHETTFN SIMKSDVDIR KDLYTNTVLS GGTTMYPGMA HRMQKEIAAL
  1021  APSMMKIRII APPKRKYSVW VGGSILASLS TFQQMWISKQ EYDESGPSIV HRKCL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POTEF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
1.7 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.7 nTPM
  • skeletal muscle: 0.2 nTPM
  • breast: 0.1 nTPM
  • epididymis: 0.1 nTPM
  • placenta: 0.1 nTPM
  • prostate: 0.1 nTPM

Single-cell type

  • undifferentiated spermatogonia: 62 nCPM
  • differentiating spermatogonia: 17 nCPM
  • lactotrophs: 13 nCPM
  • early primary spermatocytes: 12 nCPM
  • prostatic glandular cells: 7.2 nCPM
  • cytotrophoblasts: 7.1 nCPM

Immune cell

  • total PBMC: 1.6 nTPM
  • classical monocyte: 0.3 nTPM
  • non-classical monocyte: 0.3 nTPM
  • basophil: 0.2 nTPM
  • eosinophil: 0.2 nTPM
  • intermediate monocyte: 0.2 nTPM

Brain region

  • hypothalamus: 3 nTPM
  • spinal cord: 3 nTPM
  • medulla oblongata: 2.1 nTPM
  • midbrain: 1.2 nTPM
  • pons: 0.9 nTPM
  • basal ganglia: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about POTEF.

Disease | ImmuneIEDB

Conditions an epitope on POTEF was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
-2.74
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POTEF as an antibody target. Whether an autoantibody or antibody against POTEF could matter depends on whether native POTEF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POTEF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POTEF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POTEF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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