Seroatlas · Human Serome Atlas

ACTR6

Actin-related protein 6

Also known as: ARP6, ARP6_HUMAN, FLJ13433

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZN1
Gene: ACTR6
Ensembl: ENSG00000075089
Chromosome: 12
Canonical length: 396 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable nucleosome binding activity. Involved in nucleolus organization. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>Q9GZN1|ACTR6
     1  MTTLVLDNGA YNAKIGYSHE NVSVIPNCQF RSKTARLKTF TANQIDEIKD PSGLFYILPF
    61  QKGYLVNWDV QRQVWDYLFG KEMYQVDFLD TNIIITEPYF NFTSIQESMN EILFEEYQFQ
   121  AVLRVNAGAL SAHRYFRDNP SELCCIIVDS GYSFTHIVPY CRSKKKKEAI IRINVGGKLL
   181  TNHLKEIISY RQLHVMDETH VINQVKEDVC YVSQDFYRDM DIAKLKGEEN TVMIDYVLPD
   241  FSTIKKGFCK PREEMVLSGK YKSGEQILRL ANERFAVPEI LFNPSDIGIQ EMGIPEAIVY
   301  SIQNLPEEMQ PHFFKNIVLT GGNSLFPGFR DRVYSEVRCL TPTDYDVSVV LPENPITYAW
   361  EGGKLISEND DFEDMVVTRE DYEENGHSVC EEKFDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

breast: 27 nTPM
cerebral cortex: 22 nTPM
hypothalamus: 22 nTPM
kidney: 21 nTPM
midbrain: 20 nTPM
cerebellum: 20 nTPM

Single-cell type

late primary spermatocytes: 180 nCPM
early spermatids: 137 nCPM
syncytiotrophoblasts: 134 nCPM
extravillous trophoblasts: 95 nCPM
breast lactating cells: 82 nCPM
migrating cytotrophoblasts: 78 nCPM

Immune cell

T-reg: 21 nTPM
memory CD8 T-cell: 20 nTPM
naive CD8 T-cell: 20 nTPM
naive CD4 T-cell: 20 nTPM
NK-cell: 20 nTPM
MAIT T-cell: 19 nTPM

Brain region

white matter: 18 nTPM
hypothalamus: 17 nTPM
pons: 15 nTPM
cerebral cortex: 14 nTPM
midbrain: 14 nTPM
spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 1.89
DepMap mean gene effect: -0.58
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

nucleosome binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACTR6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTR6 as an antibody target. Whether an autoantibody or antibody against ACTR6 could matter depends on whether native ACTR6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTR6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTR6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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