Seroatlas · Human Serome Atlas

ACTL10

Actin-like protein 10

Also known as: ACL10_HUMAN, C20orf134

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JWF8
Gene: ACTL10
Ensembl: ENSG00000288649
Chromosome: 20
Canonical length: 245 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to be active in actin cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>Q5JWF8|ACTL10
     1  MASTALLALC STGAFSGLAV EAGAGVCHAT PIYAGHSWHQ ATFRLNVAGS TLSRYLRDLL
    61  VAANPDLLQQ ALPRKAITHL KKRSCYVSLD FEGDLRDPAR HHPASFSVGN GCCVCLSSER
   121  FRCPEPIFQP GLLGQAEQGL PALAFRALQK MPKTLRTRLA DTVVLAGGST LFPGFAERLD
   181  KELEAQCRRH GYAALRPHLV AKHGRGMAVW TGGSMVASLH SFQRRWITRA MYQECGSRLL
   241  YDVFN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTL10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

testis: 55 nTPM
pancreas: 3.4 nTPM
prostate: 2.3 nTPM
esophagus: 1.9 nTPM
salivary gland: 1.8 nTPM
small intestine: 1.4 nTPM

Single-cell type

late spermatids: 856 nCPM
early spermatids: 410 nCPM
late primary spermatocytes: 197 nCPM
salivary ionocytes: 12 nCPM
respiratory ionocytes: 10 nCPM
breast lactating cells: 7.9 nCPM

Immune cell

T-reg: 5.2 nTPM
NK-cell: 4.3 nTPM
naive B-cell: 3.6 nTPM
memory CD8 T-cell: 2.3 nTPM
eosinophil: 1.7 nTPM
memory CD4 T-cell: 1.6 nTPM

Brain region

cerebral cortex: 7.3 nTPM
medulla oblongata: 7.2 nTPM
amygdala: 6.7 nTPM
choroid plexus: 6.3 nTPM
white matter: 6.3 nTPM
hippocampal formation: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0.08
gnomAD missense Z: -0.35
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

actin cytoskeleton

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTL10 as an antibody target. Whether an autoantibody or antibody against ACTL10 could matter depends on whether native ACTL10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTL10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTL10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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