Seroatlas · Human Serome Atlas

ACTR5

Actin-related protein 5

Also known as: Arp5, ARP5_HUMAN, FLJ12785, INO80M

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H9F9
Gene
ACTR5
Ensembl
ENSG00000101442
Chromosome
20
Canonical length
607 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Involved in several processes, including DNA repair; chromatin remodeling; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Part of Ino80 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

607 residues, UniProt reviewed canonical sequence.

>Q9H9F9|ACTR5
     1  MAANVFPFRD ARAAPDPVLE AGPVAHGPLP VPLVLDNGSF QVRAGWACPG QDPGPEPRLQ
    61  FRAVCARGRG GARGASGPQV GNALGSLEPL RWMLRSPFDR NVPVNLELQE LLLDYSFQHL
   121  GVSSQGCVDH PIVLTEAVCN PLYSRQMMSE LLFECYGIPK VAYGIDSLFS FYHNKPKNSM
   181  CSGLIISSGY QCTHVLPILE GRLDAKNCKR INLGGSQAAG YLQRLLQLKY PGHLAAITLS
   241  RMEEILHEHS YIAEDYVEEL HKWRCPDYYE NNVHKMQLPF SSKLLGSTLT SEEKQERRQQ
   301  QLRRLQELNA RRREEKLQLD QERLDRLLYV QELLEDGQMD QFHKALIELN MDSPEELQSY
   361  IQKLSIAVEQ AKQKILQAEV NLEVDVVDSK PETPDLEQLE PSLEDVESMN DFDPLFSEET
   421  PGVEKPVTTV QPVFNLAAYH QLFVGTERIR APEIIFQPSL IGEEQAGIAE TLQYILDRYP
   481  KDIQEMLVQN VFLTGGNTMY PGMKARMEKE LLEMRPFRSS FQVQLASNPV LDAWYGARDW
   541  ALNHLDDNEV WITRKEYEEK GGEYLKEHCA SNIYVPIRLP KQASRSSDAQ ASSKGSAAGG
   601  GGAGEQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • testis: 12 nTPM
  • bone marrow: 9.7 nTPM
  • ovary: 8.6 nTPM
  • skin: 8.5 nTPM
  • spleen: 8.4 nTPM
  • cervix: 8 nTPM

Single-cell type

  • late primary spermatocytes: 24 nCPM
  • differentiating spermatogonia: 24 nCPM
  • myosatellite cells: 16 nCPM
  • early primary spermatocytes: 16 nCPM
  • brain inhibitory neurons: 12 nCPM
  • undifferentiated spermatogonia: 12 nCPM

Immune cell

  • gdT-cell: 12 nTPM
  • MAIT T-cell: 11 nTPM
  • myeloid DC: 11 nTPM
  • intermediate monocyte: 10 nTPM
  • memory B-cell: 9.8 nTPM
  • naive B-cell: 9.8 nTPM

Brain region

  • white matter: 11 nTPM
  • cerebral cortex: 8.4 nTPM
  • basal ganglia: 8.1 nTPM
  • cerebellum: 7.7 nTPM
  • medulla oblongata: 6.9 nTPM
  • thalamus: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
0.41
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACTR5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTR5 as an antibody target. Whether an autoantibody or antibody against ACTR5 could matter depends on whether native ACTR5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTR5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTR5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACTR5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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