Seroatlas · Human Serome Atlas

ACTR1B

Beta-centractin

Also known as: ACTY_HUMAN, Arp1B, CTRN2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P42025
Gene: ACTR1B
Ensembl: ENSG00000115073
Chromosome: 2
Canonical length: 376 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Primary cilium,Cytosol

OverviewNCBI Gene

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>P42025|ACTR1B
     1  MESYDIIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHMRVMAG ALEGDLFIGP
    61  KAEEHRGLLT IRYPMEHGVV RDWNDMERIW QYVYSKDQLQ TFSEEHPVLL TEAPLNPSKN
   121  REKAAEVFFE TFNVPALFIS MQAVLSLYAT GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI
   181  MRVDIAGRDV SRYLRLLLRK EGVDFHTSAE FEVVRTIKER ACYLSINPQK DEALETEKVQ
   241  YTLPDGSTLD VGPARFRAPE LLFQPDLVGD ESEGLHEVVA FAIHKSDMDL RRTLFANIVL
   301  SGGSTLFKGF GDRLLSEVKK LAPKDIKIKI SAPQERLYST WIGGSILASL DTFKKMWVSK
   361  KEYEEDGSRA IHRKTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTR1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 92 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 92 nTPM
skeletal muscle: 81 nTPM
cerebellum: 77 nTPM
pancreas: 71 nTPM
heart muscle: 67 nTPM
adrenal gland: 67 nTPM

Single-cell type

extravillous trophoblasts: 80 nCPM
decidual stromal cells: 72 nCPM
esophageal basal cells: 60 nCPM
esophageal suprabasal cells: 59 nCPM
enterocytes: 55 nCPM
retinal amacrine cells: 53 nCPM

Immune cell

T-reg: 30 nTPM
myeloid DC: 21 nTPM
memory CD4 T-cell: 21 nTPM
non-classical monocyte: 21 nTPM
eosinophil: 19 nTPM
memory CD8 T-cell: 19 nTPM

Brain region

cerebral cortex: 67 nTPM
hippocampal formation: 60 nTPM
amygdala: 58 nTPM
choroid plexus: 57 nTPM
pons: 55 nTPM
thalamus: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 1.04
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

ATP binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACTR1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTR1B as an antibody target. Whether an autoantibody or antibody against ACTR1B could matter depends on whether native ACTR1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTR1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTR1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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