Seroatlas · Human Serome Atlas

POTEI

POTE ankyrin domain family member I

Also known as: POTE2beta, POTEI_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CG38
Gene: POTEI
Ensembl: ENSG00000196834
Chromosome: 2
Canonical length: 1075 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in axonogenesis and cell motility. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1075 residues, UniProt reviewed canonical sequence.

>P0CG38|POTEI
     1  MVAEVDSMPA ASSVKKPFVL RSKMGKWCRH CFPCCRGSGK SNVGTSGDQD DSTMKTLRSK
    61  MGKWCCHCFP CCRGSGKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSNVGAW
   121  GDYDDSAFVE PRYHVRREDL DKLHRAAWWG KVARKDLIVM LRDTDVNKQD KQKRTALHLA
   181  SANGNSGVVK LLLDRRCQLN VLDNKKRTAL TKAVQCQEDE CALMLLEHGT DPNIPDEYGN
   241  TTLHYAIYNE DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
   301  LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH HVICQLLSDY
   361  KEKQMLKISS ENSNPEQDLK LTSEEESQRF KGSENSQPEK MSQEPEINKD GDREVEEEMK
   421  KHESNNVGLL ENLSNGVTAG NGDDGLIPQR KSRTPENQQF PDNESEEYHR ICELVSDYKE
   481  KQMPKYSSEN SNPEQDLKLT SEEESQRLKG SENGQPEKRS QEPEINKDGD RELENFMAIE
   541  EMKKHGSTHV GFPENLTNGA TAGNGDDGLI PPRKSRTPES QQFPDTENEE YHSDEQNDTQ
   601  KQFCEEQNTG ILHDEILIHE EKQIEVVEKM NSELSLSCKK EKDFLHENST LREEIAMLRL
   661  ELDTMKHQSQ LRKKKYLEDI ESVKKKNDNL LKALQLNELT MDDDTAVLVI DNGSGMCKAG
   721  FAGDDAPRAV FPSIVGRPRQ QGMMGGMHQK ESYVGKEAQS KRGILTLKYP MEHGIITNWD
   781  DMEKIWHHTF YNELRVAPEE HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAML
   841  SLYTSGRTTG IVMDSGDGVT HTVPIYDGNA LPHATLRLDL AGRELTDYLM KILTERGYRF
   901  TTMAEREIVR DIKEKLCYVA LDFEQEMAMA ASSSSLEKSY ELPDGQVITI GNEWFRCPEA
   961  LFQPCFLGME SCGIHETTFN SIMKSDVDIR KDLYTNTVLS GGTTMYPGMA HRMQKEIAAL
  1021  APSMLKIRII APPKRKYSVW VGGSILASLS TFQQMWISKQ EYDESGPSIV HRKCF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POTEI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 3.1 nTPM

Expression across tissuesHPA

Tissue

testis: 3.1 nTPM
prostate: 2.4 nTPM
heart muscle: 0.4 nTPM
stomach: 0.2 nTPM
breast: 0.1 nTPM
pancreas: 0.1 nTPM

Single-cell type

tuft cells: 12 nCPM
prostatic glandular cells: 8.5 nCPM
breast hormone-responsive cells: 2.4 nCPM
late primary spermatocytes: 2.3 nCPM
early primary spermatocytes: 1.9 nCPM
fallopian tube ciliated cells: 1.3 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

spinal cord: 7.2 nTPM
medulla oblongata: 4.4 nTPM
hypothalamus: 3.7 nTPM
midbrain: 2.3 nTPM
pons: 1.8 nTPM
basal ganglia: 1.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about POTEI.

Disease | ImmuneIEDB

Conditions an epitope on POTEI was assayed in.

multiple sclerosis B cell
onchocerciasis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -2.66
DepMap mean gene effect: -0.43
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POTEI in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ACTB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POTEI as an antibody target. Whether an autoantibody or antibody against POTEI could matter depends on whether native POTEI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POTEI is annotated as secreted, so native POTEI circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label POTEI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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