Seroatlas · Human Serome Atlas

GK5

Glycerol kinase 5

Also known as: GLPK5_HUMAN, MGC40579

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZS86
Gene: GK5
Ensembl: ENSG00000175066
Chromosome: 3
Canonical length: 529 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable glycerol kinase activity. Predicted to be involved in glycerol metabolic process; glycerol-3-phosphate biosynthetic process; and triglyceride metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>Q6ZS86|GK5
     1  MSGLLTDPEQ RAQEPRYPGF VLGLDVGSSV IRCHVYDRAA RVCGSSVQKV ENLYPQIGWV
    61  EIDPDVLWIQ FVAVIKEAVK AAGIQMNQIV GLGISTQRAT FITWNKKTGN HFHNFISWQD
   121  LRAVELVKSW NNSLLMKIFH SSCRVLHFFT RSKRLFTASL FTFTTQQTSL RLVWILQNLT
   181  EVQKAVEEEN CCFGTIDTWL LYKLTKGSVY ATDFSNASTT GLFDPYKMCW SGMITSLISI
   241  PLSLLPPVRD TSHNFGSVDE EIFGVPIPIV ALVADQQSAM FGECCFQTGD VKLTMGTGTF
   301  LDINTGNSLQ QTTGGFYPLI GWKIGQEVVC LAESNAGDTG TAIKWAQQLD LFTDAAETEK
   361  MAKSLEDSEG VCFVPSFSGL QAPLNDPWAC ASFMGLKPST SKYHLVRAIL ESIAFRNKQL
   421  YEMMKKEIHI PVRKIRADGG VCKNGFVMQM TSDLINENID RPADIDMSCL GAASLAGLAV
   481  GFWTDKEELK KLRQSEVVFK PQKKCQEYEM SLENWAKAVK RSMNWYNKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GK5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 11 nTPM
duodenum: 8.8 nTPM
epididymis: 8.5 nTPM
ovary: 8.4 nTPM
prostate: 7.8 nTPM
small intestine: 7.5 nTPM

Single-cell type

conjunctival goblet cells: 267 nCPM
prostatic glandular cells: 266 nCPM
somatotrophs: 160 nCPM
nk-cells: 139 nCPM
epicardial cells: 132 nCPM
neutrophil progenitors: 118 nCPM

Immune cell

non-classical monocyte: 2.6 nTPM
basophil: 2 nTPM
gdT-cell: 1.5 nTPM
NK-cell: 1.5 nTPM
neutrophil: 1 nTPM
MAIT T-cell: 0.7 nTPM

Brain region

choroid plexus: 22 nTPM
cerebellum: 17 nTPM
white matter: 17 nTPM
medulla oblongata: 16 nTPM
pons: 15 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.01
gnomAD missense Z: 1.95
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GK5 as an antibody target. Whether an autoantibody or antibody against GK5 could matter depends on whether native GK5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GK5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GK5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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