HSPA1B

Protein identityUniProt · HPA

UniProt accession

P0DMV9

Gene

HSPA1B

Ensembl

ENSG00000204388

Chromosome

6

Canonical length

641 aa

Protein class

Predicted intracellular proteins

Subcellular location

Vesicles,Cytosol,Perinuclear theca,Calyx,Flagellar centriole,Annulus

OverviewNCBI Gene

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

641 residues, UniProt reviewed canonical sequence.

>P0DMV9|HSPA1B
     1  MAKAAAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA
    61  LNPQNTVFDA KRLIGRKFGD PVVQSDMKHW PFQVINDGDK PKVQVSYKGE TKAFYPEEIS
   121  SMVLTKMKEI AEAYLGYPVT NAVITVPAYF NDSQRQATKD AGVIAGLNVL RIINEPTAAA
   181  IAYGLDRTGK GERNVLIFDL GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVNH
   241  FVEEFKRKHK KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA
   301  RFEELCSDLF RSTLEPVEKA LRDAKLDKAQ IHDLVLVGGS TRIPKVQKLL QDFFNGRDLN
   361  KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS LGLETAGGVM TALIKRNSTI
   421  PTKQTQIFTT YSDNQPGVLI QVYEGERAMT KDNNLLGRFE LSGIPPAPRG VPQIEVTFDI
   481  DANGILNVTA TDKSTGKANK ITITNDKGRL SKEEIERMVQ EAEKYKAEDE VQRERVSAKN
   541  ALESYAFNMK SAVEDEGLKG KISEADKKKV LDKCQEVISW LDANTLAEKD EFEHKRKELE
   601  QVCNPIISGL YQGAGGPGPG GFGAQGPKGG SGSGPTIEEV D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPA1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

782 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSPA1B.

Disease | ImmuneIEDB

Conditions an epitope on HSPA1B was assayed in.

• multiple sclerosis B cell
• type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.48

gnomAD pLI

0.01

gnomAD missense Z

1.11

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ATP metabolic process
• cellular heat acclimation
• cellular response to heat
• cellular response to oxidative stress
• cellular response to steroid hormone stimulus
• mRNA catabolic process
• negative regulation of apoptotic process
• negative regulation of cell growth
• negative regulation of cell population proliferation
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
• negative regulation of inclusion body assembly
• negative regulation of protein ubiquitination
• positive regulation of erythrocyte differentiation
• positive regulation of gene expression
• positive regulation of interleukin-8 production
• positive regulation of microtubule nucleation
• positive regulation of NF-kappaB transcription factor activity
• positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process
• positive regulation of tumor necrosis factor-mediated signaling pathway
• protein refolding
• protein stabilization
• regulation of mitotic spindle assembly
• regulation of protein ubiquitination

Molecular functions

• ATP binding
• ATP hydrolysis activity
• ATP-dependent protein disaggregase activity
• ATP-dependent protein folding chaperone
• C3HC4-type RING finger domain binding
• enzyme binding
• G protein-coupled receptor binding
• heat shock protein binding
• histone deacetylase binding
• protein folding chaperone
• RNA binding
• signaling receptor binding
• ubiquitin protein ligase binding
• unfolded protein binding
• virus receptor activity

Cellular components

• aggresome
• blood microparticle
• centriole
• centrosome
• cytoplasm
• cytosol
• endoplasmic reticulum
• extracellular exosome
• extracellular region
• ficolin-1-rich granule lumen
• focal adhesion
• inclusion body
• mitochondrion
• nuclear speck
• nucleoplasm
• nucleus
• perinuclear region of cytoplasm
• plasma membrane
• protein-containing complex
• ribonucleoprotein complex
• vesicle

Protein domainsUniProt · Pfam · InterPro

• Heat shock protein 70 family
• Heat shock protein 70, conserved site
• Heat shock protein 70kD, peptide-binding domain superfamily
• Heat shock protein 70kD, C-terminal domain superfamily
• ATPase, nucleotide binding domain
• Hsp70 protein

KeywordsUniProt

• Acetylation
• ATP-binding
• Chaperone
• Cytoplasm
• Cytoskeleton
• Host cell receptor for virus entry
• Host-virus interaction
• Methylation
• Nucleotide-binding
• Phosphoprotein
• Receptor
• Stress response

InteractionsUniProt · HPA

Protein binding partners of HSPA1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATF5
• CHCHD3
• DNAJC7
• DNAJC8
• DNAJC9
• FOXP3
• HDAC4
• HSP40
• HSP90
• IRAK1BP1
• METTL21A
• NAA10
• NEDD1
• NOD2
• PPP5C
• PRKN
• SMAD3
• TERT
• TRIM5
• TSC2
• STUB1
• HOPX
• F2RL1