Seroatlas · Protein domains

Ubiquitin-like domain

IPR000626

Definition

Ubiquitin is expressed as three different precursors: a polymeric head-to-tail concatemer of identical units (polyubiquitin), and two N-terminal ubiquitin moieties, UbL40 and UbS27, that are fused to the ribosomal polypeptides L40 and S27, respectively. Specific endopeptidases cleave these precursor molecules PMID:15571815 to release ubiquitin moieties that are identical in sequence and contribute to the ubiquitin pool PMID:16185873. Some organisms express additional ubiquitin fusion proteins PMID:12729753. Furthermore, there are several ubiquitin-like proteins derived from ubiquitin PMID:12826404. This entry represents a domain characteristic of ubiquitin (Ub) and ubiquitin-like (Ubl) proteins such as SUMO [[cite:PMID:17491593], [cite:PMID:15479240]] and Nedd8 PMID:9857030. Ubiquitin is a protein of 76 amino acid residues, found in all eukaryotic cells and whose sequence is extremely well conserved from protozoan to vertebrates. Ubiquitin acts through its post-translational attachment (ubiquitinylation) to other proteins, where these modifications alter the function, location or trafficking of the protein, or targets it for destruction by the 26S proteasome PMID:15454246. Ubiquitin is a globular protein, the last four C-terminal residues (Leu-Arg-Gly-Gly) extending from the compact structure to form a 'tail', important for its function. The latter is mediated by the covalent conjugation of ubiquitin to target proteins, by an isopeptide linkage between the C-terminal glycine and the ε-amino group of lysine residues in the target proteins.

60 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (60 proteins: gene, accession, name)

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