Seroatlas · Human Serome Atlas

IKBKB

Inhibitor of nuclear factor kappa-B kinase subunit beta

Also known as: IKK-beta, IKK2, IKKB, IKKB_HUMAN, NFKBIKB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14920
Gene
IKBKB
Ensembl
ENSG00000104365
Chromosome
8
Canonical length
756 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

756 residues, UniProt reviewed canonical sequence.

>O14920|IKBKB
     1  MSWSPSLTTQ TCGAWEMKER LGTGGFGNVI RWHNQETGEQ IAIKQCRQEL SPRNRERWCL
    61  EIQIMRRLTH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRKYLNQ FENCCGLREG
   121  AILTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEQRL IHKIIDLGYA KELDQGSLCT
   181  SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE
   241  VDIVVSEDLN GTVKFSSSLP YPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPTYGPNGCF
   301  KALDDILNLK LVHILNMVTG TIHTYPVTED ESLQSLKARI QQDTGIPEED QELLQEAGLA
   361  LIPDKPATQC ISDGKLNEGH TLDMDLVFLF DNSKITYETQ ISPRPQPESV SCILQEPKRN
   421  LAFFQLRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMNLLR NNSCLSKMKN SMASMSQQLK
   481  AKLDFFKTSI QIDLEKYSEQ TEFGITSDKL LLAWREMEQA VELCGRENEV KLLVERMMAL
   541  QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRRLREKPRD QRTEGDSQEM VRLLLQAIQS
   601  FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE KTVVRLQEKR QKELWNLLKI
   661  ACSKVRGPVS GSPDSMNASR LSQPGQLMSQ PSTASNSLPE PAKKSEELVA EAHNLCTLLE
   721  NAIQDTVREQ DQSFTALDWS WLQTEEEEHS CLEQAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IKBKB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 23 nTPM
  • spleen: 16 nTPM
  • skeletal muscle: 15 nTPM
  • esophagus: 15 nTPM
  • adrenal gland: 13 nTPM
  • parathyroid gland: 13 nTPM

Single-cell type

  • myonuclei: 153 nCPM
  • neutrophils: 145 nCPM
  • cone photoreceptor cells: 143 nCPM
  • microglia: 137 nCPM
  • papillary tip epithelial cells: 106 nCPM
  • prostatic hillock cells: 105 nCPM

Immune cell

  • plasmacytoid DC: 8.5 nTPM
  • basophil: 7.5 nTPM
  • T-reg: 5.9 nTPM
  • eosinophil: 5.7 nTPM
  • non-classical monocyte: 5.6 nTPM
  • memory CD8 T-cell: 5.5 nTPM

Brain region

  • choroid plexus: 12 nTPM
  • medulla oblongata: 9.6 nTPM
  • thalamus: 8.7 nTPM
  • white matter: 8.5 nTPM
  • midbrain: 8.1 nTPM
  • pons: 8.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IKBKB.

Disease | AllUniProt

Conditions IKBKB is implicated in, by any mechanism.

Disease | GeneticClinVar

33 pathogenic / likely-pathogenic of 859 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
2.59
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IKBKB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IKBKB as an antibody target. Whether an autoantibody or antibody against IKBKB could matter depends on whether native IKBKB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IKBKB is annotated at the cell surface, where native IKBKB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IKBKB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IKBKB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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