Seroatlas · Human Serome Atlas

PRKN

E3 ubiquitin-protein ligase parkin

Also known as: AR-JP, PARK2, parkin, PDJ, PRKN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60260
Gene
PRKN
Ensembl
ENSG00000185345
Chromosome
6
Canonical length
465 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>O60260|PRKN
     1  MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD
    61  LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA
   121  VILHTDSRKD SPPAGSPAGR SIYNSFYVYC KGPCQRVQPG KLRVQCSTCR QATLTLTQGP
   181  SCWDDVLIPN RMSGECQSPH CPGTSAEFFF KCGAHPTSDK ETSVALHLIA TNSRNITCIT
   241  CTDVRSPVLV FQCNSRHVIC LDCFHLYCVT RLNDRQFVHD PQLGYSLPCV AGCPNSLIKE
   301  LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEPDQRKV TCEGGNGLGC
   361  GFAFCRECKE AYHEGECSAV FEASGTTTQA YRVDERAAEQ ARWEAASKET IKKTTKPCPR
   421  CHVPVEKNGG CMHMKCPQPQ CRLEWCWNCG CEWNRVCMGD HWFDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 27 nTPM
  • tongue: 15 nTPM
  • heart muscle: 8.5 nTPM
  • testis: 7.9 nTPM
  • cerebral cortex: 5.8 nTPM
  • basal ganglia: 4.9 nTPM

Single-cell type

  • myonuclei: 1,514 nCPM
  • cardiomyocytes: 1,330 nCPM
  • sertoli cells: 1,217 nCPM
  • renal collecting duct intercalated cells: 1,172 nCPM
  • bergmann glia: 1,152 nCPM
  • somatotrophs: 920 nCPM

Immune cell

  • naive CD4 T-cell: 1.4 nTPM
  • eosinophil: 1.1 nTPM
  • naive CD8 T-cell: 1.1 nTPM
  • naive B-cell: 0.9 nTPM
  • memory CD8 T-cell: 0.6 nTPM
  • MAIT T-cell: 0.5 nTPM

Brain region

  • cerebral cortex: 19 nTPM
  • basal ganglia: 16 nTPM
  • hippocampal formation: 16 nTPM
  • white matter: 14 nTPM
  • amygdala: 13 nTPM
  • hypothalamus: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRKN.

Disease | AllUniProt

Conditions PRKN is implicated in, by any mechanism.

Disease | GeneticClinVar

92 pathogenic / likely-pathogenic of 558 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRKN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKN as an antibody target. Whether an autoantibody or antibody against PRKN could matter depends on whether native PRKN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRKN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRKN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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