Seroatlas · Human Serome Atlas

SUMO4

Small ubiquitin-related modifier 4

Also known as: dJ281H8.4, IDDM5, SMT3H4, SUMO4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6EEV6
Gene
SUMO4
Ensembl
ENSG00000177688
Chromosome
6
Canonical length
95 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Calyx,Connecting piece,Flagellar centriole

OverviewNCBI Gene

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>Q6EEV6|SUMO4
     1  MANEKPTEEV KTENNNHINL KVAGQDGSVV QFKIKRQTPL SKLMKAYCEP RGLSVKQIRF
    61  RFGGQPISGT DKPAQLEMED EDTIDVFQQP TGGVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUMO4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
1.2 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1.2 nTPM
  • vagina: 1.1 nTPM
  • lung: 0.9 nTPM
  • ovary: 0.9 nTPM
  • prostate: 0.9 nTPM
  • blood vessel: 0.8 nTPM

Single-cell type

  • microglia: 0.1 nCPM
  • oligodendrocyte progenitor cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • neutrophil: 2.2 nTPM
  • T-reg: 1.1 nTPM
  • memory CD4 T-cell: 1 nTPM
  • NK-cell: 1 nTPM
  • naive CD8 T-cell: 0.9 nTPM
  • memory CD8 T-cell: 0.7 nTPM

Brain region

  • medulla oblongata: 9.9 nTPM
  • cerebellum: 9.2 nTPM
  • thalamus: 9 nTPM
  • white matter: 8.9 nTPM
  • cerebral cortex: 8.3 nTPM
  • pons: 8.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SUMO4.

Disease | AllUniProt

Conditions SUMO4 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.16
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUMO4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • SAE2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUMO4 as an antibody target. Whether an autoantibody or antibody against SUMO4 could matter depends on whether native SUMO4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUMO4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUMO4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SUMO4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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