Seroatlas · Human Serome Atlas

UBB

Polyubiquitin-B

Also known as: FLJ25987, MGC8385, UBB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CG47
Gene
UBB
Ensembl
ENSG00000170315
Chromosome
17
Canonical length
229 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol,Acrosome,Equatorial segment

OverviewNCBI Gene

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>P0CG47|UBB
     1  MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN
    61  IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE GIPPDQQRLI
   121  FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL TGKTITLEVE PSDTIENVKA
   181  KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH LVLRLRGGC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
2,786 nTPM

Expression across tissuesHPA

Tissue

  • liver: 2,786 nTPM
  • skeletal muscle: 2,492 nTPM
  • bone marrow: 2,241 nTPM
  • tongue: 2,018 nTPM
  • spinal cord: 1,814 nTPM
  • midbrain: 1,702 nTPM

Single-cell type

  • late primary spermatocytes: 5,881 nCPM
  • early spermatids: 3,301 nCPM
  • erythrocytes: 3,170 nCPM
  • oocytes: 3,016 nCPM
  • late spermatids: 2,726 nCPM
  • epididymal principal cells: 2,083 nCPM

Immune cell

  • total PBMC: 7,855 nTPM
  • basophil: 5,377 nTPM
  • NK-cell: 3,305 nTPM
  • eosinophil: 3,277 nTPM
  • memory B-cell: 3,084 nTPM
  • naive B-cell: 2,891 nTPM

Brain region

  • white matter: 1,761 nTPM
  • midbrain: 1,382 nTPM
  • cerebral cortex: 1,292 nTPM
  • hypothalamus: 1,278 nTPM
  • pons: 1,276 nTPM
  • medulla oblongata: 1,173 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.56
gnomAD pLI
0.02
gnomAD missense Z
2.73
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBB as an antibody target. Whether an autoantibody or antibody against UBB could matter depends on whether native UBB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...