Seroatlas · Human Serome Atlas

UBLCP1

Ubiquitin-like domain-containing CTD phosphatase 1

Also known as: CPUB1, MGC10067, UBCP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVY7
Gene: UBLCP1
Ensembl: ENSG00000164332
Chromosome: 5
Canonical length: 318 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

Enables proteasome regulatory particle binding activity and protein serine/threonine phosphatase activity. Involved in negative regulation of ATP-dependent activity and regulation of proteasome assembly. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q8WVY7|UBLCP1
     1  MALPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV KGKPAENDVK
    61  LGALKLKPNT KIMMMGTREE SLEDVLGPPP DNDDVVNDFD IEDEVVEVEN REENLLKISR
   121  RVKEYKVEIL NPPREGKKLL VLDVDYTLFD HRSCAETGVE LMRPYLHEFL TSAYEDYDIV
   181  IWSATNMKWI EAKMKELGVS TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS
   241  EFYSKKNTIM FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELLKLTQY LKEIAKLDDF
   301  LDLNHKYWER YLSKKQGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBLCP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

tonsil: 35 nTPM
thymus: 34 nTPM
lymph node: 32 nTPM
testis: 29 nTPM
cerebral cortex: 27 nTPM
spleen: 25 nTPM

Single-cell type

neutrophils: 149 nCPM
breast lactating cells: 109 nCPM
neutrophil progenitors: 92 nCPM
early primary spermatocytes: 83 nCPM
esophageal apical cells: 76 nCPM
undifferentiated spermatogonia: 64 nCPM

Immune cell

basophil: 48 nTPM
NK-cell: 43 nTPM
neutrophil: 31 nTPM
naive CD8 T-cell: 29 nTPM
MAIT T-cell: 28 nTPM
T-reg: 28 nTPM

Brain region

cerebral cortex: 29 nTPM
thalamus: 26 nTPM
hypothalamus: 25 nTPM
white matter: 25 nTPM
pons: 25 nTPM
medulla oblongata: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.09
gnomAD missense Z: 2.06
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of ATP-dependent activity
regulation of proteasome assembly

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ubiquitin-like domain
FCP1 homology domain
HAD superfamily
Ubiquitin-like domain superfamily
HAD-like superfamily
Ubiquitin family
NLI interacting factor-like phosphatase
HAD-superfamily hydrolase, subfamily IIID
Ubiquitin-like domain-containing CTD phosphatase 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBLCP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PSMD2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBLCP1 as an antibody target. Whether an autoantibody or antibody against UBLCP1 could matter depends on whether native UBLCP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBLCP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBLCP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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