UBTD1
Ubiquitin domain-containing protein 1
Also known as: FLJ11807, UBTD1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9HAC8
- Gene
- UBTD1
- Ensembl
- ENSG00000165886
- Chromosome
- 10
- Canonical length
- 227 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Plasma membrane,Cytosol
OverviewNCBI Gene
The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. [provided by RefSeq, Mar 2014]
Canonical amino-acid sequenceUniProt
227 residues, UniProt reviewed canonical sequence.
>Q9HAC8|UBTD1
1 MGNCVGRQRR ERPAAPGHPR KRAGRNEPLK KERLKWKSDY PMTDGQLRSK RDEFWDTAPA
61 FEGRKEIWDA LKAAAYAAEA NDHELAQAIL DGASITLPHG TLCECYDELG NRYQLPIYCL
121 SPPVNLLLEH TEEESLEPPE PPPSVRREFP LKVRLSTGKD VRLSASLPDT VGQLKRQLHA
181 QEGIEPSWQR WFFSGKLLTD RTRLQETKIQ KDFVIQVIIN QPPPPQDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against UBTD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 60 nTPM
Expression across tissuesHPA
Tissue
- testis: 60 nTPM
- skin: 50 nTPM
- heart muscle: 35 nTPM
- skeletal muscle: 34 nTPM
- kidney: 33 nTPM
- lung: 30 nTPM
Single-cell type
- rod photoreceptor cells: 143 nCPM
- transitional alveolar cells: 114 nCPM
- sertoli cells: 114 nCPM
- alveolar cells type 1: 110 nCPM
- early spermatids: 98 nCPM
- cone photoreceptor cells: 85 nCPM
Immune cell
- neutrophil: 6.7 nTPM
- eosinophil: 6.4 nTPM
- classical monocyte: 2.6 nTPM
- myeloid DC: 1.4 nTPM
- basophil: 1 nTPM
- plasmacytoid DC: 0.9 nTPM
Brain region
- thalamus: 27 nTPM
- medulla oblongata: 25 nTPM
- midbrain: 23 nTPM
- cerebellum: 23 nTPM
- pons: 21 nTPM
- spinal cord: 21 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.54
- gnomAD pLI
- 0.75
- gnomAD missense Z
- 0.48
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
InteractionsUniProt · HPA
Protein binding partners of UBTD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads UBTD1 as an antibody target. Whether an autoantibody or antibody against UBTD1 could matter depends on whether native UBTD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
UBTD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label UBTD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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