Seroatlas · Human Serome Atlas

SNRNP25

U11/U12 small nuclear ribonucleoprotein 25 kDa protein

Also known as: C16orf33, SNR25_HUMAN, U11/U12-25K

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BV90
Gene: SNRNP25
Ensembl: ENSG00000161981
Chromosome: 16
Canonical length: 132 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>Q9BV90|SNRNP25
     1  MDVFQEGLAM VVQDPLLCDL PIQVTLEEVN SQIALEYGQA MTVRVCKMDG EVMPVVVVQS
    61  ATVLDLKKAI QRYVQLKQER EGGIQHISWS YVWRTYHLTS AGEKLTEDRK KLRDYGIRNR
   121  DEVSFIKKLR QK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRNP25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 123 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 123 nTPM
cerebral cortex: 99 nTPM
amygdala: 89 nTPM
heart muscle: 81 nTPM
tongue: 79 nTPM
basal ganglia: 75 nTPM

Single-cell type

hofbauer cells: 152 nCPM
esophageal basal cells: 106 nCPM
pdcs: 93 nCPM
megakaryocytes: 93 nCPM
parietal cells: 85 nCPM
gastric progenitor cells: 82 nCPM

Immune cell

plasmacytoid DC: 220 nTPM
eosinophil: 94 nTPM
naive B-cell: 75 nTPM
memory B-cell: 75 nTPM
myeloid DC: 50 nTPM
intermediate monocyte: 40 nTPM

Brain region

cerebellum: 67 nTPM
thalamus: 51 nTPM
pons: 49 nTPM
medulla oblongata: 48 nTPM
cerebral cortex: 40 nTPM
midbrain: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: -1.44
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ubiquitin-like domain
Ubiquitin-like domain superfamily
U11/U12 small nuclear ribonucleoprotein 25kDa protein
SNRNP25, ubiquitin-like domain
Ubiquitin-like domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRNP25 as an antibody target. Whether an autoantibody or antibody against SNRNP25 could matter depends on whether native SNRNP25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRNP25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNRNP25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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