Seroatlas · Human Serome Atlas

TBCB

Tubulin-folding cofactor B

Also known as: CG22, CKAP1, CKAPI, TBCB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99426
Gene: TBCB
Ensembl: ENSG00000105254
Chromosome: 19
Canonical length: 244 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q99426|TBCB
     1  MEVTGVSAPT VTVFISSSLN TFRSEKRYSR SLTIAEFKCK LELLVGSPAS CMELELYGVD
    61  DKFYSKLDQE DALLGSYPVD DGCRIHVIDH SGARLGEYED VSRVEKYTIS QEAYDQRQDT
   121  VRSFLKRSKL GRYNEEERAQ QEAEAAQRLA EEKAQASSIP VGSRCEVRAA GQSPRRGTVM
   181  YVGLTDFKPG YWIGVRYDEP LGKNDGSVNG KRYFECQAKY GAFVKPAVVT VGDFPEEDYG
   241  LDEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBCB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 386 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 386 nTPM
midbrain: 272 nTPM
amygdala: 238 nTPM
hypothalamus: 233 nTPM
hippocampal formation: 232 nTPM
cerebral cortex: 218 nTPM

Single-cell type

oocytes: 590 nCPM
late spermatids: 371 nCPM
extravillous trophoblasts: 280 nCPM
decidual stromal cells: 237 nCPM
esophageal apical cells: 225 nCPM
late primary spermatocytes: 203 nCPM

Immune cell

non-classical monocyte: 411 nTPM
T-reg: 388 nTPM
total PBMC: 358 nTPM
intermediate monocyte: 337 nTPM
eosinophil: 320 nTPM
basophil: 312 nTPM

Brain region

white matter: 315 nTPM
medulla oblongata: 242 nTPM
cerebellum: 231 nTPM
basal ganglia: 225 nTPM
pons: 222 nTPM
thalamus: 217 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0.01
gnomAD missense Z: 0.8
DepMap mean gene effect: -1.04
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ubiquitin-like domain
CAP Gly-rich domain
Ubiquitin-like domain superfamily
CAP Gly-rich domain superfamily
CAP-Gly domain
Ubiquitin-like domain
Tubulin-folding cofactor B, ubiquitin-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBCB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBCB as an antibody target. Whether an autoantibody or antibody against TBCB could matter depends on whether native TBCB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBCB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBCB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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