Seroatlas · Human Serome Atlas

ZFAND4

AN1-type zinc finger protein 4

Also known as: ANUBL1, FLJ40185, ZFAN4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XD8
Gene: ZFAND4
Ensembl: ENSG00000172671
Chromosome: 10
Canonical length: 727 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

727 residues, UniProt reviewed canonical sequence.

>Q86XD8|ZFAND4
     1  MDNRKEPPFF NDDNMGPFYY RLHFCDTMEL FIETLTGTCF ELRVSPFETV ISVKAKIRRL
    61  EGIPICRQHL IWNNMELEND YCLNDYNISE GCTLKLVLAM RGGPINTRRV PTDDPLRKMA
   121  EYLDSSRVEV WEKTSCSKQV TFLVYQEGDQ LNFFPAVDRG DGTLTPLSDS SKKIDFHLHV
   181  LRRKGEHRMS GGSMYNSDTD EDEETEPSSS GQQIIENSIT MNKMKLLKAK MKNMNLSKKP
   241  KKAVKIKPHP PVAPRPSSGS TAPSRHRLLR VLPNIGQSCS PAFGNAYPPE ISRNGISSLA
   301  TQLSAERYIS SITGEFLKED NSWENNTLSH FSSNVKLPPQ IPHLELGNDQ ELADSVLHLG
   361  SSLPRQTKHF LGNLPSSNGN IVLPSEECVT EQSLLPKVGS LASFAEGNAD EQSSGLEGAC
   421  KVNLELLLTN ADKGLKAPEQ HLKHVAGVLN GESVETSVLN YRELSPHKNR LLSPLRCSAP
   481  MSLHNSLVKP ERQSKCFEFG KLQPSSSQSL DVQNITDSSF SRTTCFQGVK VDSLGKRSDV
   541  ISKVEARDIT EMTNKASKEP VGCVNNISFL ASLAGSTSRN RLQSTRGAGR LQNSGTGLST
   601  NLQHFQEENF RKSSPQLEHT GVFLSTHGVG MNGNNAAAGK SVGECTTHHL PPVKAPLQTK
   661  KKTTNHCFLC GKKTGLASSY ECRCGNNFCA SHRYAETHGC TYDYKSAGRR YLHEANPVVN
   721  APKLPKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFAND4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

testis: 35 nTPM
cerebellum: 5.4 nTPM
lymph node: 4.6 nTPM
tonsil: 4.4 nTPM
spinal cord: 3.4 nTPM
thyroid gland: 3.1 nTPM

Single-cell type

late spermatids: 1,225 nCPM
early spermatids: 540 nCPM
late primary spermatocytes: 266 nCPM
cardiomyocytes: 99 nCPM
adrenal cortex cells: 77 nCPM
corticotrophs: 58 nCPM

Immune cell

NK-cell: 0.7 nTPM
MAIT T-cell: 0.5 nTPM
gdT-cell: 0.4 nTPM
memory B-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
non-classical monocyte: 0.4 nTPM

Brain region

cerebellum: 7.5 nTPM
medulla oblongata: 4.5 nTPM
midbrain: 4.5 nTPM
hypothalamus: 4.4 nTPM
pons: 4.3 nTPM
white matter: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: -0.68
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

Zinc finger, AN1-type
Ubiquitin-like domain
Ubiquitin domain
Ubiquitin-like domain superfamily
AN1-like Zinc finger
Ubiquitin family
AN1-like Zinc finger
AN1-type zinc finger domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFAND4 as an antibody target. Whether an autoantibody or antibody against ZFAND4 could matter depends on whether native ZFAND4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFAND4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFAND4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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