Seroatlas · Human Serome Atlas

FAU

Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

Also known as: asr1, FLJ22986, Fub1, Fubi, MNSFbeta, RPS30, RS30_HUMAN, S30

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62861
Gene
FAU
Ensembl
ENSG00000149806
Chromosome
11
Canonical length
133 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

133 residues, UniProt reviewed canonical sequence.

>P62861|FAU
     1  MQLFVRAQEL HTFEVTGQET VAQIKAHVAS LEGIAPEDQV VLLAGAPLED EATLGQCGVE
    61  ALTTLEVAGR MLGGKVHGSL ARAGKVRGQT PKVAKQEKKK KKTGRAKRRM QYNRRFVNVV
   121  PTFGKKKGPN ANS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAU can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
1,788 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 1,788 nTPM
  • ovary: 1,745 nTPM
  • pancreas: 1,522 nTPM
  • skeletal muscle: 1,450 nTPM
  • blood vessel: 1,436 nTPM
  • cervix: 1,274 nTPM

Single-cell type

  • esophageal suprabasal cells: 3,929 nCPM
  • esophageal apical cells: 3,802 nCPM
  • gastric progenitor cells: 3,750 nCPM
  • breast secretory cells: 3,615 nCPM
  • decidual stromal cells: 3,605 nCPM
  • epididymal efferent duct absorptive cells: 3,589 nCPM

Immune cell

  • total PBMC: 10,296 nTPM
  • memory B-cell: 7,058 nTPM
  • naive B-cell: 6,534 nTPM
  • naive CD4 T-cell: 5,504 nTPM
  • memory CD4 T-cell: 4,706 nTPM
  • naive CD8 T-cell: 4,379 nTPM

Brain region

  • thalamus: 593 nTPM
  • spinal cord: 587 nTPM
  • white matter: 577 nTPM
  • basal ganglia: 560 nTPM
  • medulla oblongata: 529 nTPM
  • amygdala: 502 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.85
gnomAD missense Z
1.08
DepMap mean gene effect
-2.48
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAU in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAU as an antibody target. Whether an autoantibody or antibody against FAU could matter depends on whether native FAU is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAU is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAU as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAU. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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