Seroatlas · Human Serome Atlas

SUMO2

Small ubiquitin-related modifier 2

Also known as: SMT3B, SMT3H2, SUMO2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61956
Gene: SUMO2
Ensembl: ENSG00000188612
Chromosome: 17
Canonical length: 95 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Calyx,Connecting piece,Flagellar centriole

OverviewNCBI Gene

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>P61956|SUMO2
     1  MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER QGLSMRQIRF
    61  RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGGVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUMO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 288 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 288 nTPM
ovary: 269 nTPM
thymus: 253 nTPM
esophagus: 223 nTPM
bone marrow: 217 nTPM
skeletal muscle: 215 nTPM

Single-cell type

late spermatids: 394 nCPM
late primary spermatocytes: 279 nCPM
esophageal apical cells: 202 nCPM
parietal cells: 157 nCPM
oocytes: 147 nCPM
early spermatids: 132 nCPM

Immune cell

total PBMC: 853 nTPM
basophil: 834 nTPM
eosinophil: 784 nTPM
T-reg: 704 nTPM
plasmacytoid DC: 618 nTPM
non-classical monocyte: 551 nTPM

Brain region

cerebellum: 217 nTPM
hypothalamus: 175 nTPM
white matter: 167 nTPM
cerebral cortex: 166 nTPM
spinal cord: 163 nTPM
basal ganglia: 158 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.87
gnomAD missense Z: 2.2

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUMO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUMO2 as an antibody target. Whether an autoantibody or antibody against SUMO2 could matter depends on whether native SUMO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUMO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUMO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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