Seroatlas · Human Serome Atlas

BAG1

BAG family molecular chaperone regulator 1

Also known as: BAG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99933
Gene: BAG1
Ensembl: ENSG00000107262
Chromosome: 9
Canonical length: 345 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q99933|BAG1
     1  MAQRGGARRP RGDRERLGSR LRALRPGREP RQSEPPAQRG PPPSGRPPAR STASGHDRPT
    61  RGAAAGARRP RMKKKTRRRS TRSEELTRSE ELTLSEEATW SEEATQSEEA TQGEEMNRSQ
   121  EVTRDEESTR SEEVTREEMA AAGLTVTVTH SNEKHDLHVT SQQGSSEPVV QDLAQVVEEV
   181  IGVPQSFQKL IFKGKSLKEM ETPLSALGIQ DGCRVMLIGK KNSPQEEVEL KKLKHLEKSV
   241  EKIADQLEEL NKELTGIQQG FLPKDLQAEA LCKLDRRVKA TIEQFMKILE EIDTLILPEN
   301  FKDSRLKRKG LVKKVQAFLA ECDTVEQNIC QETERLQSTN FALAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BAG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 273 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 273 nTPM
tongue: 193 nTPM
heart muscle: 176 nTPM
kidney: 157 nTPM
choroid plexus: 143 nTPM
midbrain: 134 nTPM

Single-cell type

late spermatids: 4,335 nCPM
early spermatids: 1,285 nCPM
ocular epithelial cells: 786 nCPM
urothelial cells: 447 nCPM
suprabasal keratinocytes: 429 nCPM
prostatic club cells: 395 nCPM

Immune cell

eosinophil: 54 nTPM
plasmacytoid DC: 33 nTPM
basophil: 28 nTPM
myeloid DC: 24 nTPM
non-classical monocyte: 22 nTPM
naive B-cell: 21 nTPM

Brain region

hypothalamus: 86 nTPM
basal ganglia: 84 nTPM
thalamus: 83 nTPM
midbrain: 82 nTPM
spinal cord: 81 nTPM
medulla oblongata: 78 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: -0.52
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BAG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BAG1 as an antibody target. Whether an autoantibody or antibody against BAG1 could matter depends on whether native BAG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BAG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BAG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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