Seroatlas · Human Serome Atlas

RAD23B

UV excision repair protein RAD23 homolog B

Also known as: HHR23B, HR23B, P58, RD23B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P54727
Gene
RAD23B
Ensembl
ENSG00000119318
Chromosome
9
Canonical length
409 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

409 residues, UniProt reviewed canonical sequence.

>P54727|RAD23B
     1  MQVTLKTLQQ QTFKIDIDPE ETVKALKEKI ESEKGKDAFP VAGQKLIYAG KILNDDTALK
    61  EYKIDEKNFV VVMVTKPKAV STPAPATTQQ SAPASTTAVT SSTTTTVAQA PTPVPALAPT
   121  STPASITPAS ATASSEPAPA SAAKQEKPAE KPAETPVATS PTATDSTSGD SSRSNLFEDA
   181  TSALVTGQSY ENMVTEIMSM GYEREQVIAA LRASFNNPDR AVEYLLMGIP GDRESQAVVD
   241  PPQAASTGAP QSSAVAAAAA TTTATTTTTS SGGHPLEFLR NQPQFQQMRQ IIQQNPSLLP
   301  ALLQQIGREN PQLLQQISQH QEHFIQMLNE PVQEAGGQGG GGGGGSGGIA EAGSGHMNYI
   361  QVTPQEKEAI ERLKALGFPE GLVIQAYFAC EKNENLAANF LLQQNFDED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAD23B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
143 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 143 nTPM
  • liver: 132 nTPM
  • tongue: 115 nTPM
  • bone marrow: 78 nTPM
  • placenta: 73 nTPM
  • adipose tissue: 69 nTPM

Single-cell type

  • late spermatids: 2,070 nCPM
  • neutrophils: 668 nCPM
  • early spermatids: 541 nCPM
  • esophageal apical cells: 482 nCPM
  • migrating cytotrophoblasts: 404 nCPM
  • cytotrophoblasts: 392 nCPM

Immune cell

  • neutrophil: 2.9 nTPM
  • NK-cell: 2.3 nTPM
  • T-reg: 2.2 nTPM
  • MAIT T-cell: 2.1 nTPM
  • naive B-cell: 2.1 nTPM
  • gdT-cell: 1.9 nTPM

Brain region

  • cerebellum: 110 nTPM
  • cerebral cortex: 97 nTPM
  • hypothalamus: 88 nTPM
  • white matter: 88 nTPM
  • hippocampal formation: 87 nTPM
  • thalamus: 85 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAD23B.

Disease | ImmuneIEDB

Conditions an epitope on RAD23B was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
1.75
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAD23B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAD23B as an antibody target. Whether an autoantibody or antibody against RAD23B could matter depends on whether native RAD23B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAD23B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAD23B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAD23B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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