Seroatlas · Human Serome Atlas

OASL

2'-5'-oligoadenylate synthase-like protein

Also known as: OASL_HUMAN, OASL1, p59OASL, TRIP14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15646
Gene
OASL
Ensembl
ENSG00000135114
Chromosome
12
Canonical length
514 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>Q15646|OASL
     1  MALMQELYST PASRLDSFVA QWLQPHREWK EEVLDAVRTV EEFLRQEHFQ GKRGLDQDVR
    61  VLKVVKVGSF GNGTVLRSTR EVELVAFLSC FHSFQEAAKH HKDVLRLIWK TMWQSQDLLD
   121  LGLEDLRMEQ RVPDALVFTI QTRGTAEPIT VTIVPAYRAL GPSLPNSQPP PEVYVSLIKA
   181  CGGPGNFCPS FSELQRNFVK HRPTKLKSLL RLVKHWYQQY VKARSPRANL PPLYALELLT
   241  IYAWEMGTEE DENFMLDEGF TTVMDLLLEY EVICIYWTKY YTLHNAIIED CVRKQLKKER
   301  PIILDPADPT LNVAEGYRWD IVAQRASQCL KQDCCYDNRE NPISSWNVKR ARDIHLTVEQ
   361  RGYPDFNLIV NPYEPIRKVK EKIRRTRGYS GLQRLSFQVP GSERQLLSSR CSLAKYGIFS
   421  HTHIYLLETI PSEIQVFVKN PDGGSYAYAI NPNSFILGLK QQIEDQQGLP KKQQQLEFQG
   481  QVLQDWLGLG IYGIQDSDTL ILSKKKGEAL FPAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OASL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 34 nTPM
  • stomach: 21 nTPM
  • lung: 11 nTPM
  • liver: 7.7 nTPM
  • urinary bladder: 7.2 nTPM
  • colon: 7 nTPM

Single-cell type

  • foveolar cells: 202 nCPM
  • esophageal apical cells: 110 nCPM
  • urothelial cells: 79 nCPM
  • colonocytes: 65 nCPM
  • t-cells: 48 nCPM
  • goblet cells: 42 nCPM

Immune cell

  • neutrophil: 133 nTPM
  • eosinophil: 66 nTPM
  • memory CD8 T-cell: 62 nTPM
  • gdT-cell: 53 nTPM
  • naive CD8 T-cell: 39 nTPM
  • memory CD4 T-cell: 36 nTPM

Brain region

  • spinal cord: 7.8 nTPM
  • medulla oblongata: 4 nTPM
  • pons: 3.9 nTPM
  • thalamus: 3.3 nTPM
  • white matter: 2.7 nTPM
  • basal ganglia: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.55
gnomAD pLI
0
gnomAD missense Z
0.07
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OASL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OASL as an antibody target. Whether an autoantibody or antibody against OASL could matter depends on whether native OASL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OASL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OASL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OASL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...