Seroatlas · Human Serome Atlas

UHRF1

E3 ubiquitin-protein ligase UHRF1

Also known as: FLJ21925, ICBP90, Np95, RNF106, TDRD22, UHRF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96T88
Gene
UHRF1
Ensembl
ENSG00000276043
Chromosome
19
Canonical length
793 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

793 residues, UniProt reviewed canonical sequence.

>Q96T88|UHRF1
     1  MWIQVRTMDG RQTHTVDSLS RLTKVEELRR KIQELFHVEP GLQRLFYRGK QMEDGHTLFD
    61  YEVRLNDTIQ LLVRQSLVLP HSTKERDSEL SDTDSGCCLG QSESDKSSTH GEAAAETDSR
   121  PADEDMWDET ELGLYKVNEY VDARDTNMGA WFEAQVVRVT RKAPSRDEPC SSTSRPALEE
   181  DVIYHVKYDD YPENGVVQMN SRDVRARART IIKWQDLEVG QVVMLNYNPD NPKERGFWYD
   241  AEISRKRETR TARELYANVV LGDDSLNDCR IIFVDEVFKI ERPGEGSPMV DNPMRRKSGP
   301  SCKHCKDDVN RLCRVCACHL CGGRQDPDKQ LMCDECDMAF HIYCLDPPLS SVPSEDEWYC
   361  PECRNDASEV VLAGERLRES KKKAKMASAT SSSQRDWGKG MACVGRTKEC TIVPSNHYGP
   421  IPGIPVGTMW RFRVQVSESG VHRPHVAGIH GRSNDGAYSL VLAGGYEDDV DHGNFFTYTG
   481  SGGRDLSGNK RTAEQSCDQK LTNTNRALAL NCFAPINDQE GAEAKDWRSG KPVRVVRNVK
   541  GGKNSKYAPA EGNRYDGIYK VVKYWPEKGK SGFLVWRYLL RRDDDEPGPW TKEGKDRIKK
   601  LGLTMQYPEG YLEALANRER EKENSKREEE EQQEGGFASP RTGKGKWKRK SAGGGPSRAG
   661  SPRRTSKKTK VEPYSLTAQQ SSLIREDKSN AKLWNEVLAS LKDRPASGSP FQLFLSKVEE
   721  TFQCICCQEL VFRPITTVCQ HNVCKDCLDR SFRAQVFSCP ACRYDLGRSY AMQVNQPLQT
   781  VLNQLFPGYG NGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UHRF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 63 nTPM
  • bone marrow: 26 nTPM
  • lymph node: 15 nTPM
  • tonsil: 9.6 nTPM
  • appendix: 9 nTPM
  • esophagus: 6.3 nTPM

Single-cell type

  • monocyte progenitors: 77 nCPM
  • erythrocyte progenitors: 58 nCPM
  • neutrophil progenitors: 41 nCPM
  • gastric progenitor cells: 28 nCPM
  • thymocytes: 26 nCPM
  • megakaryocyte progenitors: 25 nCPM

Immune cell

  • plasmacytoid DC: 4.8 nTPM
  • T-reg: 2.3 nTPM
  • myeloid DC: 1.3 nTPM
  • memory CD8 T-cell: 1 nTPM
  • memory CD4 T-cell: 0.8 nTPM
  • naive CD8 T-cell: 0.8 nTPM

Brain region

  • white matter: 11 nTPM
  • thalamus: 9.4 nTPM
  • medulla oblongata: 7.9 nTPM
  • midbrain: 7.7 nTPM
  • pons: 7.5 nTPM
  • basal ganglia: 7.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UHRF1.

Disease | ImmuneIEDB

Conditions an epitope on UHRF1 was assayed in.

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UHRF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UHRF1 as an antibody target. Whether an autoantibody or antibody against UHRF1 could matter depends on whether native UHRF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UHRF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UHRF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UHRF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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