NEDD8
Ubiquitin-like protein NEDD8
Also known as: Nedd-8, NEDD8_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15843
- Gene
- NEDD8
- Ensembl
- ENSG00000129559
- Chromosome
- 14
- Canonical length
- 81 aa
- Protein class
- Cancer-related genes, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Enables ubiquitin protein ligase binding activity. Acts upstream of or within protein neddylation. Located in cytosol and nucleoplasm. Biomarker of Parkinson's disease and malignant astrocytoma. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
81 residues, UniProt reviewed canonical sequence.
>Q15843|NEDD8
1 MLIKVKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK
61 ILGGSVLHLV LALRGGGGLR QLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NEDD8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 350 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 350 nTPM
- skeletal muscle: 347 nTPM
- cerebral cortex: 347 nTPM
- basal ganglia: 309 nTPM
- amygdala: 293 nTPM
- parathyroid gland: 271 nTPM
Single-cell type
- parietal cells: 182 nCPM
- gastric chief cells: 151 nCPM
- suprabasal keratinocytes: 91 nCPM
- differentiating spermatogonia: 90 nCPM
- peritubular myoid cells: 88 nCPM
- megakaryocytes: 87 nCPM
Immune cell
- total PBMC: 527 nTPM
- basophil: 464 nTPM
- eosinophil: 462 nTPM
- plasmacytoid DC: 371 nTPM
- T-reg: 328 nTPM
- memory B-cell: 313 nTPM
Brain region
- hypothalamus: 84 nTPM
- cerebral cortex: 82 nTPM
- medulla oblongata: 73 nTPM
- pons: 71 nTPM
- thalamus: 69 nTPM
- basal ganglia: 68 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.48
- gnomAD pLI
- 0.85
- gnomAD missense Z
- 2.03
- DepMap mean gene effect
- -1.67
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- anatomical structure morphogenesis
- cellular response to camptothecin
- intracellular protein localization
- modification-dependent protein catabolic process
- protein modification process
- protein neddylation
- proteolysis
- regulation of postsynapse assembly
- regulation of proteolysis
- regulation of transcription by RNA polymerase II
- ubiquitin-dependent protein catabolic process
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NEDD8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NEDD8 as an antibody target. Whether an autoantibody or antibody against NEDD8 could matter depends on whether native NEDD8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NEDD8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NEDD8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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