Seroatlas · Human Serome Atlas

ANKUB1

Protein ANKUB1

Also known as: ANKUB_HUMAN, C3orf16

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFN9
Gene: ANKUB1
Ensembl: ENSG00000206199
Chromosome: 3
Canonical length: 502 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ANKUB1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

502 residues, UniProt reviewed canonical sequence.

>A6NFN9|ANKUB1
     1  MRIFIAFEGS FEPFDVSADE TVEVVKLMIK DYFHIPLSED KQGRRYLELM YAGAALKDSW
    61  SLADVGISFC STLKCFVKEE DKPTLYVFNA VTQDTMPVME SISLLDKTVS DLRTLVTLRC
   121  GLPVSVYCLR TPRGLEMYDC NTLKDYQTDI GTTLRLDVWD GWKEFLMGCL LGQKLKVQRY
   181  LSKEGPVLKY QKRVALYIAA FCGYIELTEW ALKQGARPHE AVGVHPYRAW CHEALHADVS
   241  KCPIHAAAEA GQLLILKAFV NYSVLCLECK NAAGQTPLTI VFKHKHKDCV LYLLSKMWST
   301  VSFPKISVPM RIYIKIKQWI LRAQSHSLHK SQFCGARVFG AKVGDTVMVD GFTKPKMTSK
   361  SWHKAGNSDS QSIVLKLPSL SKQTASSKPV NPLAISQPDT RKQALKFHPL VNASSFSELQ
   421  KHQQQNQKKI TATARKKEKL IKNTYLPQVP LPPVSRVGYS HPSFFYATPS ADFLLKSSFS
   481  SFLEHSGKTP WENAIYCLAV AR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKUB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 5.6 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 5.6 nTPM
choroid plexus: 3.1 nTPM
lung: 1.1 nTPM
cervix: 0.6 nTPM
testis: 0.6 nTPM
hypothalamus: 0.3 nTPM

Single-cell type

cardiomyocytes: 703 nCPM
epicardial cells: 596 nCPM
early spermatids: 480 nCPM
myonuclei: 470 nCPM
respiratory ciliated cells: 450 nCPM
endometrial ciliated cells: 426 nCPM

Immune cell

neutrophil: 1.5 nTPM
basophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

choroid plexus: 16 nTPM
midbrain: 12 nTPM
medulla oblongata: 7.6 nTPM
spinal cord: 4.3 nTPM
white matter: 3.9 nTPM
pons: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: 0.95

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKUB1 as an antibody target. Whether an autoantibody or antibody against ANKUB1 could matter depends on whether native ANKUB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKUB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKUB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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