Seroatlas · Human Serome Atlas

RAD23A

UV excision repair protein RAD23 homolog A

Also known as: HHR23A, MGC111083, RD23A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P54725
Gene
RAD23A
Ensembl
ENSG00000179262
Chromosome
19
Canonical length
363 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

363 residues, UniProt reviewed canonical sequence.

>P54725|RAD23A
     1  MAVTITLKTL QQQTFKIRME PDETVKVLKE KIEAEKGRDA FPVAGQKLIY AGKILSDDVP
    61  IRDYRIDEKN FVVVMVTKTK AGQGTSAPPE ASPTAAPESS TSFPPAPTSG MSHPPPAARE
   121  DKSPSEESAP TTSPESVSGS VPSSGSSGRE EDAASTLVTG SEYETMLTEI MSMGYERERV
   181  VAALRASYNN PHRAVEYLLT GIPGSPEPEH GSVQESQVSE QPATEAAGEN PLEFLRDQPQ
   241  FQNMRQVIQQ NPALLPALLQ QLGQENPQLL QQISRHQEQF IQMLNEPPGE LADISDVEGE
   301  VGAIGEEAPQ MNYIQVTPQE KEAIERLKAL GFPESLVIQA YFACEKNENL AANFLLSQNF
   361  DDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAD23A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
922 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 922 nTPM
  • tongue: 418 nTPM
  • heart muscle: 126 nTPM
  • blood vessel: 101 nTPM
  • colon: 88 nTPM
  • bone marrow: 81 nTPM

Single-cell type

  • late primary spermatocytes: 351 nCPM
  • extravillous trophoblasts: 304 nCPM
  • syncytiotrophoblasts: 293 nCPM
  • esophageal basal cells: 287 nCPM
  • migrating cytotrophoblasts: 278 nCPM
  • erythrocyte progenitors: 269 nCPM

Immune cell

  • non-classical monocyte: 106 nTPM
  • intermediate monocyte: 102 nTPM
  • MAIT T-cell: 87 nTPM
  • plasmacytoid DC: 86 nTPM
  • T-reg: 82 nTPM
  • gdT-cell: 81 nTPM

Brain region

  • cerebral cortex: 77 nTPM
  • white matter: 63 nTPM
  • pons: 62 nTPM
  • medulla oblongata: 61 nTPM
  • hypothalamus: 61 nTPM
  • basal ganglia: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.18
gnomAD missense Z
1.59
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAD23A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAD23A as an antibody target. Whether an autoantibody or antibody against RAD23A could matter depends on whether native RAD23A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAD23A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAD23A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAD23A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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