Seroatlas · Human Serome Atlas

UBTD2

Ubiquitin domain-containing protein 2

Also known as: DC-UbP, MGC30022, UBTD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUN7
Gene: UBTD2
Ensembl: ENSG00000168246
Chromosome: 5
Canonical length: 234 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>Q8WUN7|UBTD2
     1  MGGCVGAQHD SSGSLNENSE GTGVALGRNQ PLKKEKPKWK SDYPMTDGQL RSKRDEFWDT
    61  APAFEGRKEI WDALKAAAHA FESNDHELAQ AIIDGANITL PHGALTECYD ELGNRYQLPV
   121  YCLAPPINMI EEKSDIETLD IPEPPPNSGY ECQLRLRLST GKDLKLVVRS TDTVFHMKRR
   181  LHAAEGVEPG SQRWFFSGRP LTDKMKFEEL KIPKDYVVQV IVSQPVQNPT PVEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBTD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

testis: 37 nTPM
cerebellum: 34 nTPM
cervix: 23 nTPM
ovary: 21 nTPM
small intestine: 21 nTPM
endometrium: 20 nTPM

Single-cell type

endometrial secretory cells: 268 nCPM
ocular epithelial cells: 189 nCPM
late spermatids: 182 nCPM
endometrial glandular cells: 168 nCPM
conjunctival goblet cells: 156 nCPM
early spermatids: 152 nCPM

Immune cell

plasmacytoid DC: 0.7 nTPM
T-reg: 0.5 nTPM
intermediate monocyte: 0.4 nTPM
myeloid DC: 0.4 nTPM
classical monocyte: 0.3 nTPM
MAIT T-cell: 0.3 nTPM

Brain region

cerebellum: 46 nTPM
basal ganglia: 13 nTPM
choroid plexus: 12 nTPM
medulla oblongata: 12 nTPM
hypothalamus: 12 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.19
gnomAD missense Z: 1
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cytoplasm

InteractionsUniProt · HPA

Protein binding partners of UBTD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GALT

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBTD2 as an antibody target. Whether an autoantibody or antibody against UBTD2 could matter depends on whether native UBTD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBTD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBTD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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