Seroatlas · Human Serome Atlas

UBL4A

Ubiquitin-like protein 4A

Also known as: DXS254E, GDX, GET5, MDY2, TMA24, UBL4, UBL4A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P11441
Gene: UBL4A
Ensembl: ENSG00000102178
Chromosome: X
Canonical length: 157 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables protein-folding chaperone binding activity. Involved in establishment of protein localization to membrane; regulation of protein stability; and ubiquitin-dependent protein catabolic process. Located in cytosol; membrane; and nucleoplasm. Part of BAT3 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

157 residues, UniProt reviewed canonical sequence.

>P11441|UBL4A
     1  MQLTVKALQG RECSLQVPED ELVSTLKQLV SEKLNVPVRQ QRLLFKGKAL ADGKRLSDYS
    61  IGPNSKLNLV VKPLEKVLLE EGEAQRLADS PPPQVWQLIS KVLARHFSAA DASRVLEQLQ
   121  RDYERSLSRL TLDDIERLAS RFLHPEVTET MEKGFSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBL4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 92 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 92 nTPM
tongue: 68 nTPM
heart muscle: 46 nTPM
cerebral cortex: 40 nTPM
pancreas: 36 nTPM
adrenal gland: 29 nTPM

Single-cell type

platelets: 436 nCPM
megakaryocytes: 210 nCPM
esophageal basal cells: 56 nCPM
esophageal suprabasal cells: 53 nCPM
extravillous trophoblasts: 52 nCPM
migrating cytotrophoblasts: 51 nCPM

Immune cell

basophil: 95 nTPM
MAIT T-cell: 47 nTPM
total PBMC: 42 nTPM
memory CD8 T-cell: 36 nTPM
NK-cell: 34 nTPM
T-reg: 34 nTPM

Brain region

cerebral cortex: 42 nTPM
white matter: 32 nTPM
thalamus: 29 nTPM
hippocampal formation: 29 nTPM
pons: 28 nTPM
basal ganglia: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0.3
gnomAD missense Z: 0.7
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBL4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBL4A as an antibody target. Whether an autoantibody or antibody against UBL4A could matter depends on whether native UBL4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBL4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBL4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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