Seroatlas · Human Serome Atlas

NFATC2IP

NFATC2-interacting protein

Also known as: ESC2, FLJ14639, NF2IP_HUMAN, NIP45, RAD60

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCF5
Gene: NFATC2IP
Ensembl: ENSG00000176953
Chromosome: 16
Canonical length: 419 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q8NCF5|NFATC2IP
     1  MAEPVGKRGR WSGGSGAGRG GRGGWGGRGR RPRAQRSPSR GTLDVVSVDL VTDSDEEILE
    61  VATARGAADE VEVEPPEPPG PVASRDNSNS DSEGEDRRPA GPPREPVRRR RRLVLDPGEA
   121  PLVPVYSGKV KSSLRLIPDD LSLLKLYPPG DEEEAELADS SGLYHEGSPS PGSPWKTKLR
   181  TKDKEEKKKT EFLDLDNSPL SPPSPRTKSR THTRALKKLS EVNKRLQDLR SCLSPKPPQG
   241  QEQQGQEDEV VLVEGPTLPE TPRLFPLKIR CRADLVRLPL RMSEPLQSVV DHMATHLGVS
   301  PSRILLLFGE TELSPTATPR TLKLGVADII DCVVLTSSPE ATETSQQLQL RVQGKEKHQT
   361  LEVSLSRDSP LKTLMSHYEE AMGLSGRKLS FFFDGTKLSG RELPADLGME SGDLIEVWG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFATC2IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 46 nTPM
spleen: 43 nTPM
tonsil: 36 nTPM
cerebellum: 35 nTPM
small intestine: 35 nTPM
lymph node: 34 nTPM

Single-cell type

early primary spermatocytes: 170 nCPM
sertoli cells: 153 nCPM
differentiating spermatogonia: 132 nCPM
pdcs: 117 nCPM
megakaryocyte progenitors: 107 nCPM
erythrocyte progenitors: 106 nCPM

Immune cell

basophil: 4.9 nTPM
plasmacytoid DC: 3.2 nTPM
NK-cell: 2.8 nTPM
T-reg: 2.4 nTPM
memory CD8 T-cell: 2.3 nTPM
naive CD4 T-cell: 2.3 nTPM

Brain region

cerebellum: 31 nTPM
thalamus: 25 nTPM
cerebral cortex: 24 nTPM
white matter: 23 nTPM
medulla oblongata: 22 nTPM
pons: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.42
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NFATC2IP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NFATC2IP as an antibody target. Whether an autoantibody or antibody against NFATC2IP could matter depends on whether native NFATC2IP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NFATC2IP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NFATC2IP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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