Seroatlas · Human Serome Atlas

ANKRD60

Ankyrin repeat domain-containing protein 60

Also known as: ANR60_HUMAN, bA196N14.3, C20orf86

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BZ19
Gene
ANKRD60
Ensembl
ENSG00000124227
Chromosome
20
Canonical length
345 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ANKRD60 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q9BZ19|ANKRD60
     1  MTRGRAWGMR RAAAGAGGAR AAGPTGGASR LHPNAGRRSG ARAGAQGCGG PRVGSADSRA
    61  LPAQPLACAR GRSQRLVCDP KAASALPDLA PDVFVLRVRL EETGEMFRVA NCRGDMTVRE
   121  LKEELDLMVG IPFNLQRLQY LDEGVLMDDT TLKFHDVVPG GIISLCIWHH DGWTELVLAA
   181  VEGDPSKLSC LGLTEDSFYR TANSEHFEGE KWKHWTSQRA FVALYVASHR GHFDAVQYLL
   241  EHGASCLSRS PLGRTPLHVA AAMGRSDCII LLLQHGASIH DRDAKGETPI SIAHRLNHTL
   301  SERQMVLLHR IAKSGIRDLN DLVMKNALQR VKSGFRSEKM TMTPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD60 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
3.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 3.5 nTPM
  • skeletal muscle: 0.2 nTPM
  • bone marrow: 0.1 nTPM
  • retina: 0.1 nTPM
  • skin: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • late spermatids: 14 nCPM
  • early spermatids: 5.4 nCPM
  • late primary spermatocytes: 3.2 nCPM
  • somatotrophs: 0.6 nCPM
  • neuroendocrine cells: 0.5 nCPM
  • cdc: 0.3 nCPM

Immune cell

  • neutrophil: 1.1 nTPM
  • eosinophil: 0.5 nTPM
  • non-classical monocyte: 0.5 nTPM
  • basophil: 0.4 nTPM
  • classical monocyte: 0.3 nTPM
  • intermediate monocyte: 0.2 nTPM

Brain region

  • white matter: 2.2 nTPM
  • cerebellum: 2.1 nTPM
  • medulla oblongata: 2 nTPM
  • cerebral cortex: 1.9 nTPM
  • hypothalamus: 1.8 nTPM
  • pons: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0
gnomAD missense Z
0.57

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD60 as an antibody target. Whether an autoantibody or antibody against ANKRD60 could matter depends on whether native ANKRD60 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD60 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD60 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD60. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...