Seroatlas · Human Serome Atlas

TBCEL

Tubulin-specific chaperone cofactor E-like protein

Also known as: LRRC35, MGC10233, TBCEL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5QJ74
Gene
TBCEL
Ensembl
ENSG00000154114
Chromosome
11
Canonical length
424 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable alpha-tubulin binding activity. Predicted to be involved in microtubule cytoskeleton organization; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>Q5QJ74|TBCEL
     1  MDQPSGRSFM QVLCEKYSPE NFPYRRGPGM GVHVPATPQG SPMKDRLNLP SVLVLNSCGI
    61  TCAGDEKEIA AFCAHVSELD LSDNKLEDWH EVSKIVSNVP QLEFLNLSSN PLNLSVLERT
   121  CAGSFSGVRK LVLNNSKASW ETVHMILQEL PDLEELFLCL NDYETVSCPS ICCHSLKLLH
   181  ITDNNLQDWT EIRKLGVMFP SLDTLVLANN HLNAIEEPDD SLARLFPNLR SISLHKSGLQ
   241  SWEDIDKLNS FPKLEEVRLL GIPLLQPYTT EERRKLVIAR LPSVSKLNGS VVTDGEREDS
   301  ERFFIRYYVD VPQEEVPFRY HELITKYGKL EPLAEVDLRP QSSAKVEVHF NDQVEEMSIR
   361  LDQTVAELKK QLKTLVQLPT SNMLLYYFDH EAPFGPEEMK YSSRALHSFG IRDGDKIYVE
   421  SKTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBCEL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 15 nTPM
  • choroid plexus: 14 nTPM
  • liver: 14 nTPM
  • testis: 12 nTPM
  • seminal vesicle: 11 nTPM
  • placenta: 9.9 nTPM

Single-cell type

  • choroid plexus epithelial cells: 172 nCPM
  • ependymal cells: 51 nCPM
  • oligodendrocytes: 50 nCPM
  • oligodendrocyte progenitor cells: 50 nCPM
  • other brain neurons: 49 nCPM
  • brain excitatory neurons: 46 nCPM

Immune cell

  • NK-cell: 0.6 nTPM
  • MAIT T-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.4 nTPM
  • naive CD4 T-cell: 0.4 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • gdT-cell: 0.3 nTPM

Brain region

  • choroid plexus: 41 nTPM
  • thalamus: 40 nTPM
  • basal ganglia: 39 nTPM
  • cerebellum: 38 nTPM
  • white matter: 37 nTPM
  • cerebral cortex: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.97
gnomAD missense Z
2.77
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBCEL as an antibody target. Whether an autoantibody or antibody against TBCEL could matter depends on whether native TBCEL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBCEL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBCEL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TBCEL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...