Seroatlas · Human Serome Atlas

DDI2

Protein DDI1 homolog 2

Also known as: DDI2_HUMAN, MGC14844

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5TDH0
Gene
DDI2
Ensembl
ENSG00000197312
Chromosome
1
Canonical length
399 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>Q5TDH0|DDI2
     1  MLLTVYCVRR DLSEVTFSLQ VDADFELHNF RALCELESGI PAAESQIVYA ERPLTDNHRS
    61  LASYGLKDGD VVILRQKENA DPRPPVQFPN LPRIDFSSIA VPGTSSPRQR QPPGTQQSHS
   121  SPGEITSSPQ GLDNPALLRD MLLANPHELS LLKERNPPLA EALLSGDLEK FSRVLVEQQQ
   181  DRARREQERI RLFSADPFDL EAQAKIEEDI RQQNIEENMT IAMEEAPESF GQVVMLYINC
   241  KVNGHPVKAF VDSGAQMTIM SQACAERCNI MRLVDRRWAG IAKGVGTQKI IGRVHLAQVQ
   301  IEGDFLPCSF SILEEQPMDM LLGLDMLKRH QCSIDLKKNV LVIGTTGSQT TFLPEGELPE
   361  CARLAYGAGR EDVRPEEIAD QELAEALQKS AEDAERQKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 25 nTPM
  • liver: 20 nTPM
  • esophagus: 15 nTPM
  • tongue: 11 nTPM
  • skin: 10 nTPM
  • adipose tissue: 10 nTPM

Single-cell type

  • myonuclei: 179 nCPM
  • erythrocyte progenitors: 158 nCPM
  • esophageal apical cells: 151 nCPM
  • prostatic glandular cells: 131 nCPM
  • prostatic hillock cells: 122 nCPM
  • thymic myoid cells: 113 nCPM

Immune cell

  • plasmacytoid DC: 1.8 nTPM
  • gdT-cell: 1.1 nTPM
  • naive B-cell: 1.1 nTPM
  • naive CD8 T-cell: 1.1 nTPM
  • MAIT T-cell: 0.9 nTPM
  • classical monocyte: 0.8 nTPM

Brain region

  • white matter: 13 nTPM
  • choroid plexus: 12 nTPM
  • cerebellum: 11 nTPM
  • pons: 11 nTPM
  • hippocampal formation: 11 nTPM
  • cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
2.73
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DDI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDI2 as an antibody target. Whether an autoantibody or antibody against DDI2 could matter depends on whether native DDI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DDI2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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