Seroatlas · Human Serome Atlas

UBL7

Ubiquitin-like protein 7

Also known as: BMSC-UbP, MGC14421, UBL7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96S82
Gene
UBL7
Ensembl
ENSG00000138629
Chromosome
15
Canonical length
380 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables protein-macromolecule adaptor activity. Involved in antiviral innate immune response. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>Q96S82|UBL7
     1  MSLSDWHLAV KLADQPLTPK SILRLPETEL GEYSLGGYSI SFLKQLIAGK LQESVPDPEL
    61  IDLIYCGRKL KDDQTLDFYG IQPGSTVHVL RKSWPEPDQK PEPVDKVAAM REFRVLHTAL
   121  HSSSSYREAV FKMLSNKESL DQIIVATPGL SSDPIALGVL QDKDLFSVFA DPNMLDTLVP
   181  AHPALVNAIV LVLHSVAGSA PMPGTDSSSR SMPSSSYRDM PGGFLFEGLS DDEDDFHPNT
   241  RSTPSSSTPS SRPASLGYSG AAGPRPITQS ELATALALAS TPESSSHTPT PGTQGHSSGT
   301  SPMSSGVQSG TPITNDLFSQ ALQHALQASG QPSLQSQWQP QLQQLRDMGI QDDELSLRAL
   361  QATGGDIQAA LELIFAGGAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
110 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 110 nTPM
  • cerebral cortex: 80 nTPM
  • heart muscle: 65 nTPM
  • spinal cord: 65 nTPM
  • amygdala: 63 nTPM
  • hippocampal formation: 61 nTPM

Single-cell type

  • late spermatids: 248 nCPM
  • late primary spermatocytes: 81 nCPM
  • early spermatids: 56 nCPM
  • extravillous trophoblasts: 50 nCPM
  • cytotrophoblasts: 48 nCPM
  • migrating cytotrophoblasts: 46 nCPM

Immune cell

  • plasmacytoid DC: 152 nTPM
  • myeloid DC: 71 nTPM
  • T-reg: 66 nTPM
  • neutrophil: 66 nTPM
  • eosinophil: 60 nTPM
  • intermediate monocyte: 59 nTPM

Brain region

  • cerebral cortex: 31 nTPM
  • pons: 30 nTPM
  • basal ganglia: 29 nTPM
  • white matter: 29 nTPM
  • midbrain: 27 nTPM
  • hippocampal formation: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
1.29
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBL7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBL7 as an antibody target. Whether an autoantibody or antibody against UBL7 could matter depends on whether native UBL7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBL7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBL7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBL7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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