Seroatlas · Human Serome Atlas

UBA52

Ubiquitin-ribosomal protein eL40 fusion protein

Also known as: CEP52, HUBCEP52, L40, MGC126879, MGC126881, MGC57125, RL40_HUMAN, RPL40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62987
Gene: UBA52
Ensembl: ENSG00000221983
Chromosome: 19
Canonical length: 128 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Nucleoplasm,Endoplasmic reticulum,Plasma membrane,Cytosol,Acrosome,Equatorial segment

OverviewNCBI Gene

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>P62987|UBA52
     1  MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN
    61  IQKESTLHLV LRLRGGIIEP SLRQLAQKYN CDKMICRKCY ARLHPRAVNC RKKKCGHTNN
   121  LRPKKKVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBA52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 2,055 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 2,055 nTPM
ovary: 1,641 nTPM
pancreas: 1,587 nTPM
skeletal muscle: 1,572 nTPM
tonsil: 1,564 nTPM
thymus: 1,385 nTPM

Single-cell type

late spermatids: 20,333 nCPM
esophageal apical cells: 5,661 nCPM
esophageal suprabasal cells: 4,722 nCPM
extravillous trophoblasts: 3,464 nCPM
early spermatids: 3,340 nCPM
esophageal basal cells: 3,325 nCPM

Immune cell

total PBMC: 4,841 nTPM
memory B-cell: 3,140 nTPM
naive B-cell: 3,039 nTPM
naive CD4 T-cell: 2,956 nTPM
memory CD4 T-cell: 2,625 nTPM
plasmacytoid DC: 2,477 nTPM

Brain region

spinal cord: 504 nTPM
white matter: 480 nTPM
medulla oblongata: 463 nTPM
thalamus: 443 nTPM
hypothalamus: 429 nTPM
basal ganglia: 409 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBA52.

Disease | ImmuneIEDB

Conditions an epitope on UBA52 was assayed in.

allergic disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.6
gnomAD missense Z: 1.88
DepMap mean gene effect: -1.54
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ubiquitin-like domain
Ubiquitin conserved site
Ubiquitin domain
Ubiquitin-like domain superfamily
Ubiquitin and ubiquitin-like
Ubiquitin family
Large ribosomal subunit protein eL40 domain
Large ribosomal subunit protein eL40 superfamily
Ribosomal L40e family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBA52 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBA52 as an antibody target. Whether an autoantibody or antibody against UBA52 could matter depends on whether native UBA52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBA52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBA52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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