Seroatlas · Human Serome Atlas

TMUB2

Transmembrane and ubiquitin-like domain-containing protein 2

Also known as: MGC3123, TMUB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q71RG4
Gene: TMUB2
Ensembl: ENSG00000168591
Chromosome: 17
Canonical length: 321 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to be involved in ERAD pathway. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q71RG4|TMUB2
     1  MISRHLQNNL MSVDPASSQA MELSDVTLIE GVGNEVMVVA GVVVLILALV LAWLSTYVAD
    61  SGSNQLLGAI VSAGDTSVLH LGHVDHLVAG QGNPEPTELP HPSEGNDEKA EEAGEGRGDS
   121  TGEAGAGGGV EPSLEHLLDI QGLPKRQAGA GSSSPEAPLR SEDSTCLPPS PGLITVRLKF
   181  LNDTEELAVA RPEDTVGALK SKYFPGQESQ MKLIYQGRLL QDPARTLRSL NITDNCVIHC
   241  HRSPPGSAVP GPSASLAPSA TEPPSLGVNV GSLMVPVFVV LLGVVWYFRI NYRQFFTAPA
   301  TVSLVGVTVF FSFLVFGMYG R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMUB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

spleen: 50 nTPM
testis: 45 nTPM
bone marrow: 41 nTPM
thyroid gland: 41 nTPM
prostate: 40 nTPM
cerebellum: 40 nTPM

Single-cell type

syncytiotrophoblasts: 119 nCPM
neutrophils: 111 nCPM
esophageal apical cells: 95 nCPM
early primary spermatocytes: 77 nCPM
hofbauer cells: 65 nCPM
tuft cells: 58 nCPM

Immune cell

basophil: 84 nTPM
neutrophil: 65 nTPM
eosinophil: 57 nTPM
classical monocyte: 30 nTPM
non-classical monocyte: 29 nTPM
intermediate monocyte: 27 nTPM

Brain region

cerebral cortex: 33 nTPM
cerebellum: 32 nTPM
thalamus: 32 nTPM
hippocampal formation: 32 nTPM
amygdala: 31 nTPM
midbrain: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: -0.32
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ERAD pathway

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMUB2 as an antibody target. Whether an autoantibody or antibody against TMUB2 could matter depends on whether native TMUB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMUB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMUB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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