UBQLN3

Protein identityUniProt · HPA

UniProt accession

Q9H347

Gene

UBQLN3

Ensembl

ENSG00000175520

Chromosome

11

Canonical length

655 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis. It has been suggested that this gene may regulate cell-cycle progression during spermatogenesis, however, it has been shown that the ortholgous mouse gene is dispensable for embryonic development and spermatogenesis. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

655 residues, UniProt reviewed canonical sequence.

>Q9H347|UBQLN3
     1  MAKGGEALPQ GSPAPVQDPH LIKVTVKTPK DKEDFSVTDT CTIQQLKEEI SQRFKAHPDQ
    61  LVLIFAGKIL KDPDSLAQCG VRDGLTVHLV IKRQHRAMGN ECPAASVPTQ GPSPGSLPQP
   121  SSIYPADGPP AFSLGLLTGL SRLGLAYRGF PDQPSSLMRQ HVSVPEFVTQ LIDDPFIPGL
   181  LSNTGLVRQL VLDNPHMQQL IQHNPEIGHI LNNPEIMRQT LEFLRNPAMM QEMIRSQDRV
   241  LSNLESIPGG YNVLCTMYTD IMDPMLNAVQ EQFGGNPFAT ATTDNATTTT SQPSRMENCD
   301  PLPNPWTSTH GGSGSRQGRQ DGDQDAPDIR NRFPNFLGII RLYDYLQQLH ENPQSLGTYL
   361  QGTASALSQS QEPPPSVNRV PPSSPSSQEP GSGQPLPEES VAIKGRSSCP AFLRYPTENS
   421  TGQGGDQDGA GKSSTGHSTN LPDLVSGLGD SANRVPFAPL SFSPTAAIPG IPEPPWLPSP
   481  AYPRSLRPDG MNPAPQLQDE IQPQLPLLMH LQAAMANPRA LQALRQIEQG LQVLATEAPR
   541  LLLWFMPCLA GTGSVAGGIE SREDPLMSED PLPNPPPEVF PALDSAELGF LSPPFLHMLQ
   601  DLVSTNPQQL QPEAHFQVQL EQLRSMGFLN REANLQALIA TGGDVDAAVE KLRQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBQLN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

151 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.01

gnomAD pLI

0

gnomAD missense Z

-1.21

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to stress
• regulation of proteasomal protein catabolic process
• ubiquitin-dependent protein catabolic process

Molecular functions

• polyubiquitin modification-dependent protein binding

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Ubiquitin-like domain
• Heat shock chaperonin-binding
• UBA-like superfamily
• Ubiquilin
• Ubiquitin-associated domain
• Ubiquitin-like domain superfamily
• Ubiquitin family
• UBA/TS-N domain
• Ubiquilin-1-like domain