Seroatlas · Human Serome Atlas

HERPUD2

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

Also known as: FLJ22313, HERP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSE4
Gene: HERPUD2
Ensembl: ENSG00000122557
Chromosome: 7
Canonical length: 406 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli,Nucleoli rim

OverviewNCBI Gene

Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q9BSE4|HERPUD2
     1  MDQSGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL TKDQRLVYSG
    61  RLLPDHLQLK DILRKQDEYH MVHLVCTSRT PPSSPKSSTN RESHEALASS SNSSSDHSGS
   121  TTPSSGQETL SLAVGSSSEG LRQRTLPQAQ TDQAQSHQFP YVMQGNVDNQ FPGQAAPPGF
   181  PVYPAFSPLQ MLWWQQMYAH QYYMQYQAAV SAQATSNVNP TQPTTSQPLN LAHVPGEEPP
   241  PAPNLVAQEN RPMNENVQMN AQGGPVLNEE DFNRDWLDWM YTFSRAAILL SIVYFYSSFS
   301  RFIMVMGAML LVYLHQAGWF PFRQEGGHQQ APNNNAEVNN DGQNANNLEL EEMERLMDDG
   361  LEDESGEDGG EDASAIQRPG LMASAWSFIT TFFTSLIPEG PPQVAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HERPUD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 32 nTPM
ovary: 29 nTPM
pancreas: 27 nTPM
spleen: 23 nTPM
testis: 23 nTPM
liver: 22 nTPM

Single-cell type

late spermatids: 985 nCPM
early spermatids: 373 nCPM
neutrophils: 228 nCPM
t-cells: 207 nCPM
esophageal apical cells: 179 nCPM
neutrophil progenitors: 166 nCPM

Immune cell

eosinophil: 23 nTPM
NK-cell: 14 nTPM
MAIT T-cell: 13 nTPM
neutrophil: 13 nTPM
memory CD8 T-cell: 12 nTPM
non-classical monocyte: 11 nTPM

Brain region

white matter: 45 nTPM
choroid plexus: 44 nTPM
basal ganglia: 43 nTPM
cerebellum: 41 nTPM
thalamus: 41 nTPM
medulla oblongata: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.95
gnomAD missense Z: 1.06
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HERPUD2 as an antibody target. Whether an autoantibody or antibody against HERPUD2 could matter depends on whether native HERPUD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HERPUD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HERPUD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...