UBD

Protein identityUniProt · HPA

UniProt accession

O15205

Gene

UBD

Ensembl

ENSG00000213886

Chromosome

6

Canonical length

165 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a protein which contains two ubiquitin-like domains and appears to have similar function to ubiquitin. Through covalent attachment, the encoded protein targets other proteins for 26S proteasome degradation. This protein has been implicated to function in many cellular processes, including caspase-dependent apoptosis, formation of aggresomes, mitotic regulation, and dendritic cell maturation. Upregulation of this gene may promote inflammation in chronic kidney disease and has been observed in many cancer types. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>O15205|UBD
     1  MAPNASCLCV HVRSEEWDLM TFDANPYDSV KKIKEHVRSK TKVPVQDQVL LLGSKILKPR
    61  RSLSSYGIDK EKTIHLTLKV VKPSDEELPL FLVESGDEAK RHLLQVRRSS SVAQVKAMIE
   121  TKTGIIPETQ IVTCNGKRLE DGKMMADYGI RKGNLLFLAC YCIGG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

142 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBD.

Disease | ImmuneIEDB

Conditions an epitope on UBD was assayed in.

• abacavir allergy T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.84

gnomAD pLI

0.01

gnomAD missense Z

0.24

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• aggresome assembly
• myeloid dendritic cell differentiation
• positive regulation of apoptotic process
• positive regulation of canonical NF-kappaB signal transduction
• protein modification by small protein conjugation
• protein ubiquitination
• proteolysis
• regulation of mitotic cell cycle phase transition
• response to tumor necrosis factor
• response to type II interferon
• ubiquitin-dependent protein catabolic process

Molecular functions

• proteasome binding

Cellular components

• aggresome
• cytoplasm
• cytosol
• fibrillar center
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Ubiquitin-like domain
• Ubiquitin domain
• Ubiquitin-like domain superfamily
• Ubiquitin family
• Ubiquitin D

KeywordsUniProt

• Acetylation
• Cytoplasm
• Nucleus
• Repeat
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of UBD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NUB1
• SQSTM1
• HDAC6
• TP53
• MAPK8IP2
• UBE2Z