Seroatlas · Human Serome Atlas

TINCR

Ubiquitin domain-containing protein TINCR

Also known as: FLJ90734, LINC00036, NCRNA00036, onco-lncRNA-16, PLAC2, TINCR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A2R8Y7D0
Gene
TINCR
Ensembl
ENSG00000223573
Chromosome
19
Canonical length
120 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene produces a spliced long non-coding RNA that binds RNAs. This transcript interacts with staufen-1 protein to regulate the stability of mRNAs for genes involved in the differentiation of epidermal tissue. Variation in this gene may be associated with cancer progression. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

120 residues, UniProt reviewed canonical sequence.

>A0A2R8Y7D0|TINCR
     1  MEGLRRGLSR WKRYHIKVHL ADEALLLPLT VRPRDTLSDL RAQLVGQGVS SWKRAFYYNA
    61  RRLDDHQTVR DARLQDGSVL LLVSDPSEAQ RLTPAIPALW EAEASRSLES RSSRPAWPTW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TINCR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
134 nTPM

Expression across tissuesHPA

Tissue

  • skin: 134 nTPM
  • esophagus: 38 nTPM
  • vagina: 24 nTPM
  • cervix: 20 nTPM
  • placenta: 17 nTPM
  • salivary gland: 9.6 nTPM

Single-cell type

  • syncytiotrophoblasts: 698 nCPM
  • extravillous trophoblasts: 389 nCPM
  • esophageal apical cells: 361 nCPM
  • migrating cytotrophoblasts: 226 nCPM
  • cytotrophoblasts: 174 nCPM
  • suprabasal keratinocytes: 121 nCPM

Immune cell

  • basophil: 3.1 nTPM
  • neutrophil: 2.2 nTPM
  • plasmacytoid DC: 1.2 nTPM
  • memory B-cell: 0.9 nTPM
  • naive B-cell: 0.9 nTPM
  • NK-cell: 0.6 nTPM

Brain region

  • thalamus: 36 nTPM
  • cerebral cortex: 29 nTPM
  • pons: 26 nTPM
  • midbrain: 26 nTPM
  • amygdala: 24 nTPM
  • basal ganglia: 23 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TINCR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TINCR as an antibody target. Whether an autoantibody or antibody against TINCR could matter depends on whether native TINCR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TINCR is annotated at the cell surface, where native TINCR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TINCR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TINCR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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