Seroatlas · Human Serome Atlas

DDI1

Protein DDI1 homolog 1

Also known as: DDI1_HUMAN, FLJ36017

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WTU0
Gene: DDI1
Ensembl: ENSG00000170967
Chromosome: 11
Canonical length: 396 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable aspartic-type endopeptidase activity. Involved in several processes, including cellular response to hydroxyurea; regulation of DNA stability; and regulation of protein stability. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>Q8WTU0|DDI1
     1  MLITVYCVRR DLSEVTFSLQ VSPDFELRNF KVLCEAESRV PVEEIQIIHM ERLLIEDHCS
    61  LGSYGLKDGD IVVLLQKDNV GPRAPGRAPN QPRVDFSGIA VPGTSSSRPQ HPGQQQQRTP
   121  AAQRSQGLAS GEKVAGLQGL GSPALIRSML LSNPHDLSLL KERNPPLAEA LLSGSLETFS
   181  QVLMEQQREK ALREQERLRL YTADPLDREA QAKIEEEIRQ QNIEENMNIA IEEAPESFGQ
   241  VTMLYINCKV NGHPLKAFVD SGAQMTIMSQ ACAERCNIMR LVDRRWAGVA KGVGTQRIIG
   301  RVHLAQIQIE GDFLQCSFSI LEDQPMDMLL GLDMLRRHQC SIDLKKNVLV IGTTGTQTYF
   361  LPEGELPLCS RMVSGQDESS DKEITHSVMD SGRKEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 1,504 nCPM
early spermatids: 393 nCPM
late primary spermatocytes: 259 nCPM
epicardial cells: 4.5 nCPM
early primary spermatocytes: 2.5 nCPM
leydig cells: 1.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.8 nTPM
pons: 1.6 nTPM
midbrain: 1 nTPM
hypothalamus: 0.7 nTPM
medulla oblongata: 0.7 nTPM
cerebral cortex: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

aspartic-type endopeptidase activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DDI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDI1 as an antibody target. Whether an autoantibody or antibody against DDI1 could matter depends on whether native DDI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...