Seroatlas · Human Serome Atlas

UBQLNL

Ubiquilin-like protein

Also known as: MGC20470, MGC26958, UBQLN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYU4
Gene: UBQLNL
Ensembl: ENSG00000175518
Chromosome: 11
Canonical length: 475 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q8IYU4|UBQLNL
     1  MWHAISRTSR MSQSGCPSGL LADKNISSSA TRVIVKTAGN QKDFMVADDI SVRQFKEMLL
    61  AHFQCQMDQL VLVFMGCLLK DHDTLSQRGI MDGHTIYLVI KSKQGSRSLA HSFRDLPTND
   121  PCHRDRNTKG NSSRVHQPTG MNQAPVELAH FVGSDAPKVH TQNLEVSHPE CKAQMLENPS
   181  IQRLLSNMEF MWQFISEHLD TQQLMQQNPE VSRLLLDNSE ILLQTLELAR NLAMIQEIMQ
   241  IQQPSQNLEY PLNPQPYLGL ETMPGGNNAL GQNYADINDQ MLNSMQDPFG GNPFTALLAG
   301  QVLEQVQSSP PPPPPSQEQQ DQLTQHPATR VIYNSSGGFS SNTSANDTLN KVNHTSKANT
   361  AMISTKGQSH ICATRQPAWI PALPSIELTQ QLQEEYKDAT VSLSSSRQTL KGDLQLSDEQ
   421  SSSQITGGMM QLLMNNPYLA AQIMLFTSMP QLSEQWRQQL PTFLQQTQIS DLLSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBQLNL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
ovary: 2.4 nTPM
prostate: 1.4 nTPM
spleen: 1.4 nTPM
cervix: 1.3 nTPM
epididymis: 1.1 nTPM

Single-cell type

late spermatids: 6.7 nCPM
early spermatids: 1.8 nCPM
late primary spermatocytes: 0.3 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

midbrain: 1.2 nTPM
choroid plexus: 1.1 nTPM
medulla oblongata: 1.1 nTPM
pons: 1.1 nTPM
hypothalamus: 1 nTPM
spinal cord: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: -0.55
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBQLNL as an antibody target. Whether an autoantibody or antibody against UBQLNL could matter depends on whether native UBQLNL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBQLNL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBQLNL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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