SUMO1
Small ubiquitin-related modifier 1
Also known as: GMP1, OFC10, PIC1, SMT3C, SMT3H3, SUMO-1, SUMO1_HUMAN, UBL1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P63165
- Gene
- SUMO1
- Ensembl
- ENSG00000116030
- Chromosome
- 2
- Canonical length
- 101 aa
- Protein class
- Disease related genes, Human disease related genes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nuclear membrane,Nucleoli,Nuclear bodies
OverviewNCBI Gene
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
101 residues, UniProt reviewed canonical sequence.
>P63165|SUMO1
1 MSDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES YCQRQGVPMN
61 SLRFLFEGQR IADNHTPKEL GMEEEDVIEV YQEQTGGHST VLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SUMO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 163 nTPM
Expression across tissuesHPA
Tissue
- liver: 163 nTPM
- bone marrow: 126 nTPM
- kidney: 110 nTPM
- thymus: 104 nTPM
- skeletal muscle: 101 nTPM
- cerebral cortex: 99 nTPM
Single-cell type
- esophageal apical cells: 342 nCPM
- parietal cells: 322 nCPM
- extravillous trophoblasts: 321 nCPM
- basal keratinocytes: 293 nCPM
- suprabasal keratinocytes: 291 nCPM
- migrating cytotrophoblasts: 290 nCPM
Immune cell
- total PBMC: 395 nTPM
- T-reg: 330 nTPM
- eosinophil: 285 nTPM
- memory B-cell: 278 nTPM
- neutrophil: 258 nTPM
- NK-cell: 247 nTPM
Brain region
- cerebral cortex: 100 nTPM
- cerebellum: 94 nTPM
- hypothalamus: 88 nTPM
- white matter: 87 nTPM
- choroid plexus: 86 nTPM
- basal ganglia: 84 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about SUMO1.
Disease | AllUniProt
Conditions SUMO1 is implicated in, by any mechanism.
- Non-syndromic orofacial cleft 10 (OFC10) MIM:613705
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.46
- gnomAD pLI
- 0.86
- gnomAD missense Z
- 1.51
- DepMap mean gene effect
- -0.18
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to cadmium ion
- cellular response to heat
- DNA repair
- negative regulation of action potential
- negative regulation of DNA-templated transcription
- negative regulation of protein import into nucleus
- negative regulation of transcription by RNA polymerase II
- negative regulation of transcription initiation by RNA polymerase II
- PML body organization
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of protein-containing complex assembly
- protein localization to nuclear pore
- protein stabilization
- protein sumoylation
- regulation of calcium ion transmembrane transport
- regulation of cardiac muscle cell contraction
- regulation of protein stability
- roof of mouth development
Molecular functions
- enzyme binding
- potassium channel regulator activity
- protein tag activity
- RNA binding
- small protein activating enzyme binding
- transporter activator activity
- ubiquitin protein ligase binding
- ubiquitin-like protein ligase binding
- ubiquitin-specific protease binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SUMO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SUMO1 as an antibody target. Whether an autoantibody or antibody against SUMO1 could matter depends on whether native SUMO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SUMO1 is annotated at the cell surface, where native SUMO1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label SUMO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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