Seroatlas · Human Serome Atlas

TMUB1

Transmembrane and ubiquitin-like domain-containing protein 1

Also known as: C7orf21, HOPS, SB144, TMUB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVT8
Gene: TMUB1
Ensembl: ENSG00000164897
Chromosome: 7
Canonical length: 246 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Involved in ERAD pathway. Predicted to be located in several cellular components, including centrosome; postsynaptic membrane; and recycling endosome. Predicted to be active in postsynaptic recycling endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>Q9BVT8|TMUB1
     1  MTLIEGVGDE VTVLFSVLAC LLVLALAWVS THTAEGGDPL PQPSGTPTPS QPSAAMAATD
    61  SMRGEAPGAE TPSLRHRGQA AQPEPSTGFT ATPPAPDSPQ EPLVLRLKFL NDSEQVARAW
   121  PHDTIGSLKR TQFPGREQQV RLIYQGQLLG DDTQTLGSLH LPPNCVLHCH VSTRVGPPNP
   181  PCPPGSEPGP SGLEIGSLLL PLLLLLLLLL WYCQIQYRPF FPLTATLGLA GFTLLLSLLA
   241  FAMYRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMUB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 130 nTPM

Expression across tissuesHPA

Tissue

liver: 130 nTPM
pancreas: 91 nTPM
skeletal muscle: 81 nTPM
pituitary gland: 66 nTPM
stomach: 65 nTPM
small intestine: 54 nTPM

Single-cell type

enterocytes: 176 nCPM
esophageal apical cells: 124 nCPM
colonocytes: 115 nCPM
cytotrophoblasts: 107 nCPM
syncytiotrophoblasts: 105 nCPM
migrating cytotrophoblasts: 95 nCPM

Immune cell

eosinophil: 24 nTPM
T-reg: 12 nTPM
naive B-cell: 11 nTPM
memory CD4 T-cell: 8.7 nTPM
naive CD4 T-cell: 8.7 nTPM
memory CD8 T-cell: 6.4 nTPM

Brain region

thalamus: 45 nTPM
medulla oblongata: 45 nTPM
cerebral cortex: 42 nTPM
pons: 40 nTPM
amygdala: 39 nTPM
midbrain: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0.04
gnomAD missense Z: 0.8
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ERAD pathway

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMUB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMUB1 as an antibody target. Whether an autoantibody or antibody against TMUB1 could matter depends on whether native TMUB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMUB1 is annotated at the cell surface, where native TMUB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMUB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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