Seroatlas · Human Serome Atlas

IQUB

IQ motif and ubiquitin-like domain-containing protein

Also known as: FLJ35834, IQUB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA54
Gene: IQUB
Ensembl: ENSG00000164675
Chromosome: 7
Canonical length: 791 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles,Cytosol,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Involved in flagellated sperm motility and mating. Predicted to be located in sperm flagellum. Predicted to be part of radial spoke. Predicted to be active in acrosomal vesicle and motile cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

791 residues, UniProt reviewed canonical sequence.

>Q8NA54|IQUB
     1  MSNQQEKYEA QNIVNSTEES DDAFDTVTIP VPSEEPQESD QTEEHESGIE QFSESHAIHV
    61  EEQSDQSFSS LEPDNEQLME EVISPRQVSY TPQHHEKQYA MQRPNDDSLA FLDKIKSVKE
   121  SLQESVEDSL ATVKVVLIPV GQEIVIPFKV DTILKYLKDH FSHLLGIPHS VLQIRYSGKI
   181  LKNNETLVQH GVKPQEIVQV EIFSTNPDLY PVRRIDGLTD VSQIITVTVQ TGLDQYQQVP
   241  VEIVKSDFHK PFLGGFRHKV TGVEYHNAGT QTVPKRIPER LSIFCRDTQT VFQKKNLQQT
   301  TNTTSTQMTN IGVYVSNMTD KLVTPGKYFS AAEYHAQRLK AVIVIQTYYR QWHAKIFVEN
   361  LRRQKSLRLE WETQQELRKI REKEEWIKLD YHRRHNPKTN EDFEFLYNAL EFWRQEELTR
   421  INQSFTGAER KAALCELLEK ETQIIASIGR HRYIAYMANQ EAAIQAFLDK CSAPKIWRTP
   481  NGKTIEMDTQ FTIRARELQN IYKCIMLKNI SQDERLDVLL TLKHTVKEHE CKLTQEILEL
   541  IDREVDLMMR GVKHHNLEGL RKRIATLFFH YIKTPLFNPE VAKYLKVPQD PLKFYKKIYF
   601  CHSCQLYLPS TEFSVSSTSR RIYRCRNCIN LQNEAQKRES FLKYKCLLQQ LYYTEADYED
   661  DSKIAFLMQL QDIQYLTENI WASQSVLSAC DNLSDLVMVR WNKSLEWSPW NCILLTKDEA
   721  AAHLKLTSIE EGYERSFIHK IKHKHILAKN YFSQVPVLAS FILDDGEIDE IRWKYHSDTT
   781  PKIIESQRPP H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQUB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

testis: 31 nTPM
fallopian tube: 4.7 nTPM
kidney: 2.8 nTPM
thyroid gland: 2.8 nTPM
choroid plexus: 2.3 nTPM
parathyroid gland: 1.6 nTPM

Single-cell type

late primary spermatocytes: 394 nCPM
late spermatids: 259 nCPM
early spermatids: 256 nCPM
respiratory ciliated cells: 222 nCPM
ependymal cells: 182 nCPM
fallopian tube ciliated cells: 152 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 11 nTPM
midbrain: 6.7 nTPM
medulla oblongata: 6.3 nTPM
cerebellum: 5.8 nTPM
spinal cord: 4.5 nTPM
cerebral cortex: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: -0.1
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ubiquitin-like domain
Ubiquitin-like domain superfamily
Ubiquitin family
IQ motif and ubiquitin-like domain-containing protein
IQ motif and ubiquitin-like domain-containing protein, helical domain
IQUB-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IQUB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQUB as an antibody target. Whether an autoantibody or antibody against IQUB could matter depends on whether native IQUB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQUB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQUB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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